Gene
tncb
- ID
- ZDB-GENE-980526-104
- Name
- tenascin Cb
- Symbol
- tncb Nomenclature History
- Previous Names
-
- tenc
- tnc
- etID309720.5 (1)
- wu:fk04d02
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including axon development; positive regulation of synaptic assembly at neuromuscular junction; and regulation of neuron projection development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including adaxial cell; central nervous system; hypochord; myoseptum; and neural crest cell. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schweitzer et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3513 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| hu3580 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| hu3583 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1576 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8813 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20437 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20438 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33617 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33618 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40443 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tncb | Nemoz-Billet et al., 2024 | |
| MO1-tncb | N/A | (2) |
| MO2-tncb | N/A | (2) |
| MO3-tncb | N/A | Yu et al., 2011 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 56 | Alliance | Deafness, autosomal dominant 56 | 615629 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | EGF-like domain, extracellular | Extracellular Matrix Regulatory Proteins | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen-like, C-terminal | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Tenascin, EGF-like domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QHI1 | InterPro | 1720 | ||||||||||
| UniProtKB:A0A8M6YY54 | InterPro | 1628 | ||||||||||
| UniProtKB:F1QYE2 | InterPro | 1811 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-195I19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-166O17 | ZFIN Curated Data | |
| Encodes | EST | fk04d02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195114 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130907 (1) | 6347 nt | ||
| Genomic | GenBank:CT737232 (1) | 147186 nt | ||
| Polypeptide | UniProtKB:F1QYE2 (1) | 1811 aa |
- Nemoz-Billet, L., Balland, M., Gilquin, L., Gillet, B., Stévant, I., Guillon, E., Hughes, S., Carpentier, G., Vaganay, E., Sohm, F., Misiak, V., Gonzalez-Melo, M.J., Koch, M., Ghavi-Helm, Y., Bretaud, S., Ruggiero, F. (2024) Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons. Proceedings of the National Academy of Sciences of the United States of America. 121:e2314588121e2314588121
- Kraus, J.M., Giovannone, D., Rydzik, R., Balsbaugh, J.L., Moss, I.L., Schwedler, J.L., Bertrand, J.Y., Traver, D., Hankenson, K.D., Crump, J.G., Youngstrom, D.W. (2022) Notch signaling enhances bone regeneration in the zebrafish mandible. Development (Cambridge, England). 149(5)
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Félix, R.C., Anjos, L., Costa, R.A., Letsiou, S., Power, D.M. (2021) Cartilage Acidic Protein a Novel Therapeutic Factor to Improve Skin Damage Repair?. Marine drugs. 19(10):
- Joshi, B., Wagh, G., Kaur, H., Patra, C. (2021) Zebrafish Model to Study Angiotensin II-Mediated Pathophysiology. Biology. 10(11):
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
- Mukherjee, D., Wagh, G., Mokalled, M.H., Kontarakis, Z., Dickson, A.L., Rayrikar, A., Günther, S., Poss, K.D., Stainier, D.Y.R., Patra, C. (2020) Ccn2a/Ctgfa is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. Development (Cambridge, England). 148(2):
- Song, J., Eghan, K., Lee, S., Park, J.S., Yoon, S., Pimtong, W., Kim, W.K. (2020) A Phenotypic and Genotypic Evaluation of Developmental Toxicity of Polyhexamethylene Guanidine Phosphate Using Zebrafish Embryo/Larvae. Toxics. 8(2):
- Sun, J., She, P., Liu, X., Gao, B., Jin, D., Zhong, T.P. (2020) Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis. International Journal of Molecular Sciences. 22(1):
- Tsata, V., Kroehne, V., Wehner, D., Rost, F., Lange, C., Hoppe, C., Kurth, T., Reinhardt, S., Petzold, A., Dahl, A., Loeffler, M., Reimer, M.M., Brand, M. (2020) Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord. Development (Cambridge, England). 147(24):
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