Gene

tncb

ID

ZDB-GENE-980526-104

Name

tenascin Cb

Symbol

tncb Nomenclature History

Previous Names

tenc
tnc
etID309720.5 (1)
wu:fk04d02

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Acts upstream of or within several processes, including axon development; positive regulation of synaptic assembly at neuromuscular junction; and regulation of neuron projection development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including adaxial cell; central nervous system; hypochord; myoseptum; and neural crest cell. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Schweitzer et al., 2005
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tncb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 56	Alliance	Deafness, autosomal dominant 56	615629

Associated With tncb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain	IPR003961	Fibronectin type III
Domain	IPR013111	EGF-like domain, extracellular
Domain	IPR041161	Tenascin, EGF-like domain
Family	IPR050991	Extracellular Matrix Regulatory Proteins
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	EGF-like domain	EGF-like domain, extracellular	Extracellular Matrix Regulatory Proteins	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Fibrinogen-like, C-terminal	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like fold	Tenascin, EGF-like domain
UniProtKB:E9QHI1 InterPro	1720
UniProtKB:A0A8M6YY54 InterPro	1628
UniProtKB:F1QYE2 InterPro	1811

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tnc-201 (1) Ensembl	Ensembl	6,229 nt	Select Tool ZFIN BLAST
mRNA	tnc-202 (1) Ensembl	Ensembl	6,899 nt	Select Tool ZFIN BLAST
mRNA	tnc-205 (1) Ensembl	Ensembl	5,384 nt	Select Tool ZFIN BLAST
mRNA	tnc-207 (1) Ensembl	Ensembl	6,783 nt	Select Tool ZFIN BLAST
mRNA	tnc-208 (1) Ensembl	Ensembl	6,780 nt	Select Tool ZFIN BLAST
mRNA	tnc-209 (1) Ensembl	Ensembl	6,347 nt	Select Tool ZFIN BLAST
ncRNA	tnc-003 (1) Ensembl	Ensembl	524 nt	Select Tool ZFIN BLAST
ncRNA	tnc-004 (1) Ensembl	Ensembl	763 nt	Select Tool ZFIN BLAST
ncRNA	tnc-005 (1) Ensembl	Ensembl	749 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations