Gene

terf2ip

ID

ZDB-GENE-131121-641

Name

telomeric repeat binding factor 2, interacting protein

Symbol

terf2ip Nomenclature History

Previous Names

RAP1 (1)
zmp:0000000584

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have telomeric DNA binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Predicted to localize to cytoplasm and shelterin complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF2IP (TERF2 interacting protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Wagner et al., 2017

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With terf2ip Human Ortholog

No data available

Associated With terf2ip Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001357	BRCT domain
Domain	IPR015010	Rap1 Myb domain
Domain	IPR021661	TRF2-interacting telomeric protein/Rap1, C-terminal
Family	IPR039595	TE2IP/Rap1
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily
Homologous_superfamily	IPR036420	BRCT domain superfamily
Homologous_superfamily	IPR038104	TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily