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ZFIN ID: ZDB-PUB-170425-4
The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
Wagner, K.D., Ying, Y., Leong, W., Jiang, J., Hu, X., Chen, Y., Michiels, J.F., Lu, Y., Gilson, E., Wagner, N., Ye, J.
Date: 2017
Source: Aging   9(4): 1219-1232 (Journal)
Registered Authors: Chen, Yi
Keywords: brain aging, development, shelterin, telomere
MeSH Terms:
  • Aging/genetics*
  • Animals
  • Female
  • Gene Expression Regulation, Developmental/genetics*
  • Male
  • Organ Specificity
  • Pregnancy
  • Telomere Homeostasis
  • Telomeric Repeat Binding Protein 2/biosynthesis*
  • Telomeric Repeat Binding Protein 2/genetics
  • Zebrafish Proteins/biosynthesis*
  • Zebrafish Proteins/genetics*
PubMed: 28437249 Full text @ Aging (Albany NY)
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in Emaintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging.