Gene
sema6ba
- ID
- ZDB-GENE-131024-1
- Name
- sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
- Symbol
- sema6ba Nomenclature History
- Previous Names
-
- si:ch211-168n16.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be active in plasma membrane. Is expressed in brain; forebrain; hindbrain; midbrain; and retinal ganglion cell. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human SEMA6B (semaphorin 6B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hamanaka et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17007 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33030 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38358 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39939 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sema6ba | Hamanaka et al., 2020 | |
| CRISPR2-sema6ba | Hamanaka et al., 2020 | |
| CRISPR3-sema6ba | Hamanaka et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Epilepsy, progressive myoclonic, 11 | 618876 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Plexin repeat | Sema domain | Sema domain superfamily | Semaphorin | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A286Y9T7 | InterPro | 872 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema6ba-201
(1)
|
Ensembl | 1,720 nt | ||
| mRNA |
sema6ba-202
(1)
|
Ensembl | 2,619 nt | ||
| mRNA |
sema6ba-203
(1)
|
Ensembl | 2,688 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-168N16 | ||
| Contained in | BAC | DKEY-232N5 | ZFIN Curated Data | |
| Contained in | BAC | RP71-45H24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001366315 (1) | 5187 nt | ||
| Genomic | GenBank:CT027824 (2) | 171318 nt | ||
| Polypeptide | UniProtKB:A0A286Y9T7 (1) | 872 aa |
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Zheng, Y.Q., Suo, G.H., Liu, D., Li, H.Y., Wu, Y.J., Ni, H. (2022) Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience. 15:848257
- Hamanaka, K., Imagawa, E., Koshimizu, E., Miyatake, S., Tohyama, J., Yamagata, T., Miyauchi, A., Ekhilevitch, N., Nakamura, F., Kawashima, T., Goshima, Y., Mohamed, A.R., Ch'ng, G.S., Fujita, A., Azuma, Y., Yasuda, K., Imamura, S., Nakashima, M., Saitsu, H., Mitsuhashi, S., Mizuguchi, T., Takata, A., Miyake, N., Matsumoto, N. (2020) De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. American journal of human genetics. 106(4):549-558
- Shi, W.J., Jiang, Y.X., Huang, G.Y., Zhao, J.L., Zhang, J.N., Liu, Y.S., Xie, L., Ying, G.G. (2018) Dydrogesterone causes male bias and accelerates sperm maturation in zebrafish (Danio rerio). Environmental science & technology. 52(15):8903-8911
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Ebert, A.M., Lamont, R.E., Childs, S.J., and McFarlane, S. (2012) Neuronal expression of class 6 semaphorins in zebrafish. Gene expression patterns : GEP. 12(3-4):117-122
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