ZFIN ID: ZDB-FIG-201130-90
Hamanaka et al., 2020 - De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. American journal of human genetics   106(4):549-558 Full text @ Am. J. Hum. Genet.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Pec-fin

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + CRISPR1-sema6ba standard conditions Prim-5 embryo development delayed, abnormal
Prim-5 head decreased size, abnormal
WT + CRISPR1-sema6ba + CRISPR7-sema6bb standard conditions Prim-5 embryo development delayed, abnormal
Prim-5 head decreased size, abnormal
WT + CRISPR2-sema6ba + CRISPR3-sema6ba standard conditions Prim-5 head decreased size, abnormal
Prim-5 whole organism apoptotic process increased occurrence, abnormal
Prim-5 whole organism decreased length, abnormal
Pec-fin optic tectum decreased area, abnormal
WT + CRISPR2-sema6ba + CRISPR3-sema6ba + CRISPR8-sema6bb + CRISPR9-sema6bb standard conditions Prim-5 head decreased size, abnormal
Prim-5 whole organism apoptotic process increased occurrence, abnormal
Prim-5 whole organism decreased length, abnormal
Pec-fin optic tectum decreased area, abnormal
WT + CRISPR7-sema6bb standard conditions Prim-5 embryo development delayed, abnormal
Prim-5 head decreased size, abnormal
WT + CRISPR8-sema6bb + CRISPR9-sema6bb standard conditions Prim-5 whole organism apoptotic process increased occurrence, abnormal
Pec-fin optic tectum decreased area, abnormal
Full text @ Am. J. Hum. Genet.