Gene
havcr2
- ID
- ZDB-GENE-091204-20
- Name
- hepatitis A virus cellular receptor 2
- Symbol
- havcr2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylserine binding activity. Predicted to be involved in apoptotic cell clearance and cytoskeletal rearrangement involved in phagocytosis, engulfment. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Yin et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37337 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| T-cell lymphoma, subcutaneous panniculitis-like | 618398 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ALN7
|
208 | |||||
|
UniProtKB:E7FEV9
|
231 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
havcr2-201
(1)
|
Ensembl | 1,450 nt | ||
| mRNA |
havcr2-202
(1)
|
Ensembl | 801 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-havcr2 |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cdh17:havcr2-RFP) |
|
| 1 | Yin et al., 2016 | |
| Tg(ubb:LOXP-EGFP-havcr2-LOXP-RFP) |
| 1 | Yin et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-222K23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003200873 (1) | 1167 nt | ||
| Genomic | GenBank:CU463029 (1) | 66900 nt | ||
| Polypeptide | UniProtKB:E7FEV9 (1) | 231 aa |
- Cai, H., Chen, Y., Feng, Y., Asadi, M., Kaufman, L., Lee, K., Kehrer, T., Miorin, L., Garcia-Sastre, A., Gusella, G.L., Gu, L., Ni, Z., Mou, S., He, J.C., Zhou, W. (2022) SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation. Molecular therapy : the journal of the American Society of Gene Therapy. 31(3):774-787
- Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176
- Ren, Q., Gao, D., Mou, L., Zhang, S., Zhang, M., Li, N., Sik, A., Jin, M., Liu, K. (2021) Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European Journal of Pharmacology. 912:174589
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Vaishnu Devi, D., Viswanathan, P. (2019) Sulphated polysaccharide from Sargassum myriocystum confers protection against gentamicin-induced nephrotoxicity in adult zebrafish. Environmental Toxicology and Pharmacology. 72:103269
- Xu, X.G., Hu, J.F., Ma, J.X., Nie, L., Shao, T., Xiang, L.X., Shao, J.Z. (2016) Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 196(4):1686-99
- Yin, W., Naini, S.M., Chen, G., Hentschel, D.M., Humphreys, B.D., Bonventre, J.V. (2016) Mammalian Target of Rapamycin Mediates Kidney Injury Molecule 1-Dependent Tubule Injury in a Surrogate Model. Journal of the American Society of Nephrology : JASN. 27(7):1943-57
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