Gene
terf1
- ID
- ZDB-GENE-090612-2
- Name
- telomeric repeat binding factor (NIMA-interacting) 1
- Symbol
- terf1 Nomenclature History
- Previous Names
-
- wu:fb74c04
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables telomeric DNA binding activity. Predicted to be involved in negative regulation of telomeric D-loop disassembly and telomere maintenance via telomerase. Predicted to act upstream of or within telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of nuclear telomere cap complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF1 (telomeric repeat binding factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wagner et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-terf1 | Ma et al., 2022 | |
| MO1-terf1 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8N7TFE0 | InterPro | 379 |
| UniProtKB:A0A8M9PXV3 | InterPro | 386 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-171B20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-192J17 | ZFIN Curated Data | |
| Encodes | EST | fb74c04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_690237 (1) | 1580 nt | ||
| Genomic | GenBank:CR318587 (1) | 164331 nt | ||
| Polypeptide | UniProtKB:A0A8M9PXV3 (1) | 386 aa |
- Ma, J., Tang, D., Gao, P., Liang, S., Zhang, R. (2022) Knockout of Shelterin subunit genes in zebrafish results in distinct outcomes. Biochemical and Biophysical Research Communications. 617:22-29
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Hu, X., Gao, S., Wang, P., Zhou, Y., Chen, K., Chen, Q., Wang, B., Hu, W., Cheng, P., Eid, R., Giraud-Panis, M.J., Wang, L., Gilson, E., Ye, J., Lu, Y. (2021) The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Biochimie. 190:12-19
- Kappei, D., Scheibe, M., Paszkowski-Rogacz, M., Bluhm, A., Gossmann, T.I., Dietz, S., Dejung, M., Herlyn, H., Buchholz, F., Mann, M., Butter, F. (2017) Phylointeractomics reconstructs functional evolution of protein binding. Nature communications. 8:14334
- Wagner, K.D., Ying, Y., Leong, W., Jiang, J., Hu, X., Chen, Y., Michiels, J.F., Lu, Y., Gilson, E., Wagner, N., Ye, J. (2017) The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Aging. 9(4):1219-1232
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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