ZFIN is now using GRCz12tu for Genomic Data

Gene

sox6

ID

ZDB-GENE-081120-6

Name

SRY-box transcription factor 6

Symbol

sox6 Nomenclature History

Previous Names

sox6b (1)
fc35a10
fc50e03
wu:fc35a10
wu:fc50e03

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within adipose tissue development; muscle cell fate specification; and skeletal muscle tissue development. Predicted to be active in nucleus. Is expressed in intermuscular bone; muscle; pharyngeal arch 3-7; somite; and telencephalon. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX6 (SRY-box transcription factor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sox6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Tolchin-Le Caignec syndrome	618971

Associated With sox6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Family	IPR051356	SOX/SOX-like transcription factors
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B2CNY6	InterPro
UniProtKB:F8W2H3	InterPro	768
UniProtKB:A0A8M1NI90	InterPro	785
UniProtKB:A0AB32TRN6	InterPro	816
UniProtKB:A0AB32TRQ1	InterPro	817
UniProtKB:A0AB32TSK4	InterPro	805
UniProtKB:A0AB32TT03	InterPro	806
UniProtKB:A0AB32TV27	InterPro	814
UniProtKB:A0AB32TWV8	InterPro	837
UniProtKB:A0AB32TXE9	InterPro	834
UniProtKB:A0AB32TYJ0	InterPro	817
UniProtKB:A0AB32TYM8	InterPro	789
UniProtKB:A0AB32TYP5	InterPro	836
UniProtKB:A0AB32TZS8	InterPro	836
UniProtKB:A0AC58FZP6	InterPro	803
UniProtKB:A0AC58FZQ0	InterPro	804
UniProtKB:A0AC58FZQ2	InterPro	805
UniProtKB:A0AC58FZQ3	InterPro	803
UniProtKB:A0AC58FZQ4	InterPro	805
UniProtKB:A0AC58FZQ6	InterPro	802
UniProtKB:A0AC58FZQ7	InterPro	788
UniProtKB:A0AC58FZQ8	InterPro	804
UniProtKB:A0AC58FZR2	InterPro	786
UniProtKB:A0AC58FZR4	InterPro	785
UniProtKB:A0AC58FZR5	InterPro	786
UniProtKB:A0AC58FZR8	InterPro	786
UniProtKB:A0AC58FZR9	InterPro	788
UniProtKB:A0AC58FZS3	InterPro	782
UniProtKB:A0AC58FZS6	InterPro	785
UniProtKB:A0AC58FZS8	InterPro	782
UniProtKB:A0AC58FZS9	InterPro	785
UniProtKB:A0AC58FZT0	InterPro	784
UniProtKB:A0AC58FZT3	InterPro	781
UniProtKB:A0AC58FZT4	InterPro	782
UniProtKB:A0AC58FZT5	InterPro	781
UniProtKB:A0AC58FZT7	InterPro	769
UniProtKB:A0AC58FZT9	InterPro	801
UniProtKB:A0AC58FZU0	InterPro	766
UniProtKB:A0AC58FZU1	InterPro	768
UniProtKB:A0AC58FZU8	InterPro	765
UniProtKB:A0AC58FZV4	InterPro	785
UniProtKB:A0AC58FZX1	InterPro	768
UniProtKB:A0AC58FZY8	InterPro	788
UniProtKB:A0AC58G000	InterPro	783
UniProtKB:A0AC58G010	InterPro	802
UniProtKB:A0AC58G015	InterPro	765
UniProtKB:A0AC58G017	InterPro	802
UniProtKB:A0AC58G018	InterPro	784
UniProtKB:A0AC58G029	InterPro	805
UniProtKB:A0AC58G030	InterPro	801
UniProtKB:A0AC58G031	InterPro	769
UniProtKB:A0AC58G035	InterPro	786
UniProtKB:A0AC58G043	InterPro	785
UniProtKB:A0AC58G045	InterPro	788
UniProtKB:A0AC58G048	InterPro	768
UniProtKB:A0AC58G054	InterPro	783
UniProtKB:A0AC58G058	InterPro	768
UniProtKB:A0AC58G067	InterPro	766

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sox6-201 (1) Ensembl	Ensembl	2,350 nt	Select Tool ZFIN BLAST
mRNA	sox6-203 (1) Ensembl	Ensembl	6,184 nt	Select Tool ZFIN BLAST
mRNA	sox6-205 (1) Ensembl	Ensembl	749 nt	Select Tool ZFIN BLAST
mRNA	sox6-206 (1) Ensembl	Ensembl	7,908 nt	Select Tool ZFIN BLAST
mRNA	sox6-207 (1) Ensembl	Ensembl	2,385 nt	Select Tool ZFIN BLAST
mRNA	sox6-208 (1) Ensembl	Ensembl	3,004 nt	Select Tool ZFIN BLAST
mRNA	sox6-209 (1) Ensembl	Ensembl	2,639 nt	Select Tool ZFIN BLAST
mRNA	sox6-210 (1) Ensembl	Ensembl	3,045 nt	Select Tool ZFIN BLAST
ncRNA	sox6-002 (1) Ensembl	Ensembl	874 nt	Select Tool ZFIN BLAST
ncRNA	sox6-003 (1) Ensembl	Ensembl	724 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-sox6		sox6		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations