ZFIN ID: ZDB-GENE-081120-6
Gene Name: SRY-box transcription factor 6
Gene Symbol: sox6    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: sox6b (1), fc35a10, fc50e03, wu:fc35a10, wu:fc50e03

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in adipose tissue development; muscle cell fate specification; and skeletal muscle tissue development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in malignant glioma. Is expressed in fast muscle cell; myotome; pharyngeal arch 3-7; and somite. Orthologous to human SOX6 (SRY-box transcription factor 6).
Genome Resources: Alliance (1),  Gene:567154 (1),  Ensembl(GRCz11):ENSDARG00000015536 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 7 publications
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
i291 Unknown Unknown Unknown ZINC_FINGER_NUCLEASE
i292 Unknown Unknown Unknown ZINC_FINGER_NUCLEASE
la016058Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la016060Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025941Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9376 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20951 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38612 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44663 Point Mutation Unknown Unknown ENU
    sa45277 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tud38Gt Transgenic Insertion Intron 4 Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sox6 N/A 2
    DISEASE ASSOCIATED WITH sox6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sox6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal muscle tissue development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR009071 High mobility group box domain
    Family IPR027153 Transcription factor SOX-5/6
    Homologous_superfamily IPR036910 High mobility group box domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sox6-203 (1)    Ensembl 6184
    sox6-205 (1)    Ensembl 749
    sox6-206 (1)    Ensembl 7908
    ncRNA sox6-002 (1)    Ensembl 874
    sox6-003 (1)    Ensembl 724
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-sox6 Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox6
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.5sox6:EGFP) sox6 EGFP Danio rerio 1 3
    Tg(-2.8sox6:EGFP) sox6 EGFP Danio rerio 1 3
    Tg(-2.8sox6:mCherry) sox6 mCherry Danio rerio 1 3
    Tg(-2sox6:EGFP) sox6 EGFP Danio rerio 1 3
    Tg(-7.6sox6:EGFP) sox6 EGFP Danio rerio 1 5
    Tg(sox6:mCherry) sox6 mCherry Danio rerio 1 3
    Tg(UAS:sox6-EGFP) UAS EGFPsox6 Danio rerio 1 2
    Tg1(-2.8sox6:EGFP-UTR-sox6) sox6 EGFP Danio rerio 1 3
    Tg2(-2.8sox6:EGFP-UTR-sox6) sox6 EGFP Danio rerio 1 3
    Tg3(-2.8sox6:EGFP-UTR-sox6) sox6 EGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    sox6 Contained in: [BAC] DKEY-48H11 (1) (order this), DKEY-246O4 (1) (order this), DKEYP-93A2 (1)
    sox6 Encodes: [EST] fc35a10, fc50e03
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123009 (1) 2350 bp
    Genomic GenBank:BX537340 (1) 192070 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QLT0 (1) 816 aa
    Sequence Information (all 31)
    ORTHOLOGY for sox6 ( Chr: 7 )
    CITATIONS (44)