Gene

sox6

ID

ZDB-GENE-081120-6

Name

SRY-box transcription factor 6

Symbol

sox6 Nomenclature History

Previous Names

sox6b (1)
fc35a10
fc50e03
wu:fc35a10
wu:fc50e03

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have DNA binding activity. Involved in adipose tissue development; muscle cell fate specification; and skeletal muscle tissue development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in malignant glioma. Is expressed in fast muscle cell; myotome; pharyngeal arch 3-7; and somite. Orthologous to human SOX6 (SRY-box transcription factor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sox6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Tolchin-Le Caignec syndrome	618971

Associated With sox6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Family	IPR051356	SOX/SOX-like transcription factors
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Length	High mobility group box domain	High mobility group box domain superfamily	SOX/SOX-like transcription factors
UniProtKB:B2CNY6 InterPro
UniProtKB:F8W2H3 InterPro	768

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sox6-201 (1) Ensembl	Ensembl	2,350 nt	Select Tool ZFIN BLAST
mRNA	sox6-203 (1) Ensembl	Ensembl	6,184 nt	Select Tool
mRNA	sox6-205 (1) Ensembl	Ensembl	749 nt	Select Tool
mRNA	sox6-206 (1) Ensembl	Ensembl	7,908 nt	Select Tool
mRNA	sox6-207 (1) Ensembl	Ensembl	2,385 nt	Select Tool ZFIN BLAST
mRNA	sox6-208 (1) Ensembl	Ensembl	3,004 nt	Select Tool ZFIN BLAST
mRNA	sox6-209 (1) Ensembl	Ensembl	2,639 nt	Select Tool ZFIN BLAST
mRNA	sox6-210 (1) Ensembl	Ensembl	3,045 nt	Select Tool ZFIN BLAST
ncRNA	sox6-002 (1) Ensembl	Ensembl	874 nt	Select Tool
ncRNA	sox6-003 (1) Ensembl	Ensembl	724 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-sox6		sox6		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations