Gene

wasa

ID
ZDB-GENE-081104-419
Name
WASP actin nucleation promoting factor a
Symbol
wasa Nomenclature History
Previous Names
  • si:dkey-48j7.6
  • wasp2 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity. Predicted to be involved in several processes, including actin cortical patch assembly; actin cortical patch localization; and positive regulation of actin nucleation. Predicted to localize to actin cortical patch and actin filament. Is expressed in hematopoietic system; leukocyte; neuromast; and thrombocyte. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Orthologous to human WAS (WASP actin nucleation promoting factor).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 1 from Cvejic et al., 2008
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wasa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thrombocytopenia Alliance Thrombocytopenia, X-linked 313900
thrombocytopenia Alliance Thrombocytopenia, X-linked, intermittent 313900
Wiskott-Aldrich syndrome Alliance Wiskott-Aldrich syndrome 301000
Neutropenia, severe congenital, X-linked 300299
Associated With wasa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000095 CRIB domain
Domain IPR000697 WH1/EVH1 domain
Domain IPR003124 WH2 domain
Domain IPR033927 WASP family, EVH1 domain
Family IPR027641 Wiskott-Aldrich syndrome protein
Homologous_superfamily IPR011026 Wiscott-Aldrich syndrome protein, C-terminal
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR036936 CRIB domain superfamily
Domain Details Per Protein
Protein Length CRIB domain CRIB domain superfamily PH-like domain superfamily WASP family, EVH1 domain WH1/EVH1 domain WH2 domain Wiscott-Aldrich syndrome protein, C-terminal Wiskott-Aldrich syndrome protein
UniProtKB:F1Q6U7 630
UniProtKB:A0A2R8RW54 509
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations