Gene

appl2

ID

ZDB-GENE-081016-2

Name

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Symbol

appl2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have gamma-tubulin binding activity. Predicted to be involved in signaling. Localizes to endosome. Is expressed in hindbrain; peripheral olfactory organ; and spinal cord. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Schenck et al., 2008

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Schenck et al., 2008
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With appl2 Human Ortholog

No data available

Associated With appl2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR004148	BAR domain
Domain	IPR006020	PTB/PI domain
Domain	IPR047236	DCC-interacting protein 13-alpha/beta, PH domain
Domain	IPR047237	DCC-interacting protein 13-alpha/beta, PTB domain
Domain	IPR047239	DCC-interacting protein 13-beta, BAR domain
Family	IPR047181	DCC-interacting protein 13-alpha/beta
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR027267	AH/BAR domain superfamily

Domain Details Per Protein

Protein	Length	AH/BAR domain superfamily	BAR domain	DCC-interacting protein 13-alpha/beta	DCC-interacting protein 13-alpha/beta, PH domain	DCC-interacting protein 13-alpha/beta, PTB domain	DCC-interacting protein 13-beta, BAR domain	PH-like domain superfamily	Pleckstrin homology domain	PTB/PI domain
UniProtKB:B2XCM0 InterPro	662
UniProtKB:F1RB27 InterPro	662

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-appl2	monoclonal	appl2		Mouse	WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations