ZFIN ID: ZDB-GENE-080403-1
Gene Name: nuclear receptor subfamily 0, group B, member 2a
Gene Symbol: nr0b2a    Nomenclature History

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Previous Names: NR0B2-A (1), nr0b2a (1), gb:bc058069, SHP-A (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have transcription corepressor activity and transcription factor binding activity. Predicted to be involved in circadian rhythm; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nucleus. Is expressed in heart and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2).
Genome Resources: Alliance (1),  Gene:403010 (1),  Ensembl(GRCz11):ENSDARG00000044685 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (3 images) from Thisse et al., 2008 [bc058069]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH nr0b2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
obesity Alliance Obesity, mild, early-onset 601665
DISEASE ASSOCIATED WITH nr0b2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component host cell nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nr0b2a-201 (1)    Ensembl 3063
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nr0b2a No data available
MARKER RELATIONSHIPS
nr0b2a Contained in: [BAC] CH73-112L20 (1)
nr0b2a Encodes: [EST] bc058069 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001256191 (1)
Genomic GenBank:CU104704 (1) 45100 nt
Select Tool
Polypeptide UniProtKB:Q6PEG7 (1) 265 aa
Sequence Information (all 9)
ORTHOLOGY for nr0b2a ( Chr: 16 )
CITATIONS (24)