Gene
chata
- ID
- ZDB-GENE-080102-2
- Name
- choline O-acetyltransferase a
- Symbol
- chata Nomenclature History
- Previous Names
-
- baj
- chat
- unm tk64
- unm_tk64
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable choline O-acetyltransferase activity. Involved in locomotory behavior. Predicted to be active in cytoplasm and neuron projection. Is expressed in brain; neurons; post-vent region; spinal cord; and spinal cord neural tube. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase).
- Genome Resources
- Note
-
Yokogawa et al. (2007) identified the chat gene with Ensembl ENSDARG00000015854 on Chr. 13.
- Comparative Information
-
- All Expression Data
- 24 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22323 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31935 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45487 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tf247 | Allele with one point mutation | Acceptor Splice Site of Intron 2 | Unknown | ENU | |
| tk64 | Allele with one point mutation | Exon 3 | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-chata | N/A | Wang et al., 2008 |
| MO2-chata | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myasthenic syndrome 6 | Alliance | Myasthenic syndrome, congenital, 6, presynaptic | 254210 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital myasthenic syndrome | chatatk64/tk64 (AB) | standard conditions | Joshi et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR039551 | Choline/carnitine acyltransferase domain |
| Family | IPR000542 | Acyltransferase ChoActase/COT/CPT |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
| Homologous_superfamily | IPR042231 | Choline/Carnitine o-acyltransferase, domain 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyltransferase ChoActase/COT/CPT | Chloramphenicol acetyltransferase-like domain superfamily | Choline/carnitine acyltransferase domain | Choline/Carnitine o-acyltransferase, domain 2 |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QF55 | InterPro | 391 | ||||
| UniProtKB:A0A8M9Q9G1 | InterPro | 637 | ||||
| UniProtKB:B2ZGJ1 | InterPro | 637 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(chata:GAL4-VP16) |
|
| 2 | (7) | |
| Tg(chata:GFP-GAL4FF) |
|
| 1 | Nikaido et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-222I16 | ||
| Contained in | BAC | CH211-232K3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130719 (1) | 1914 nt | ||
| Genomic | GenBank:BX855592 (1) | 159646 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q9G1 (1) | 637 aa |
- Gamba, B.F.G., Pickler, K.P., Lodetti, G., Farias, A.C.S., Teixeira, A.G., Bernardo, H.T., Dondossola, E.R., Cararo, J.H., Luchiari, A.C., Rosemberg, D.B., Rico, E.P. (2024) Embryonic alcohol exposure alters cholinergic neurotransmission and memory in adult zebrafish. Behavioural brain research. 474:115176
- Sui, J., Zhan, L., Ji, S., Wu, W., Chen, Y., Yun, F., Liang, W., Wang, J., Cao, M., Shen, D., Zhang, Q. (2024) Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations. CNS neuroscience & therapeutics. 30:e14583e14583
- Yao, Y., Baronio, D., Chen, Y.C., Jin, C., Panula, P. (2023) The Roles of Histamine Receptor 1 (hrh1) in Neurotransmitter System Regulation, Behavior, and Neurogenesis in Zebrafish. Molecular neurobiology. 60(11):6660-6675
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Zhang, H., Wang Haifang, H., Shen, X., Jia, X., Yu, S., Qiu, X., Wang, Y., Du, J., Yan, J., He, J. (2021) The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain. eLIFE. 10:
- Gagnaire, B., Arcanjo, C., Cavalié, I., Camilleri, V., Simon, O., Dubourg, N., Floriani, M., Adam-Guillermin, C. (2020) Effects of gamma ionizing radiation exposure on Danio rerio embryo-larval stages - comparison with tritium exposure. Journal of hazardous materials. 408:124866
- Liu, S., Yu, M., Xie, X., Ru, Y., Ru, S. (2020) Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Chemosphere. 253:126635
- Pípal, M., Legradi, J., Smutná, M., Kočí, T., Priebojová, J., Bláhová, L., Krauss, M., Hilscherová, K. (2020) Neurobehavioral effects of cyanobacterial biomass field extracts on zebrafish embryos and potential role of retinoids. Aquatic toxicology (Amsterdam, Netherlands). 228:105613
- Rima, M., Lattouf, Y, Abi Younes, M., Bullier, E., Legendre, P., Mangin, J.M., Hong, E. (2020) Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific Reports. 10(1):15338
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