Gene
col15a1b
- ID
- ZDB-GENE-070912-689
- Name
- collagen, type XV, alpha 1b
- Symbol
- col15a1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within eye development and regulation of motor neuron axon guidance. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including aortic arch; digestive system; nervous system; neural plate; and neural tube. Orthologous to human COL15A1 (collagen type XV alpha 1 chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb491 (27 images)
- IMAGE:7158238 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014870Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11640 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12573 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30818 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa39823 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39824 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa39825 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-col15a1b | N/A | Gonzalez-Nunez et al., 2010 |
| MO2-col15a1b | N/A | Guillon et al., 2016 |
| MO3-col15a1b | N/A | Guillon et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010515 | Collagenase NC10/endostatin |
| Domain | IPR045463 | Collagen type XV/XVIII, trimerization domain |
| Domain | IPR048287 | Thrombospondin-like, N-terminal domain |
| Family | IPR050149 | Collagen superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
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Domain Details Per Protein
| Protein | Length | Collagenase NC10/endostatin | Collagen superfamily | Collagen triple helix repeat | Collagen type XV/XVIII, trimerization domain | Concanavalin A-like lectin/glucanase domain superfamily | C-type lectin fold | C-type lectin-like/link domain superfamily | Thrombospondin-like, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:D3GN36
|
1169 | ||||||||
|
UniProtKB:A0A8M2BIM9
|
1259 | ||||||||
|
UniProtKB:A0A8M3APP4
|
1315 | ||||||||
|
UniProtKB:A0A8M2BII4
|
1301 | ||||||||
|
UniProtKB:A0A8M3B7P8
|
1303 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
col15a1b-201
(1)
|
Ensembl | 3,738 nt | ||
| mRNA |
col15a1b-202
(1)
|
Ensembl | 4,560 nt | ||
| mRNA |
col15a1b-203
(1)
|
Ensembl | 3,513 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-col15a1b | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-88C5 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-93C5 | Bretaud et al., 2011 | |
| Contained in | BAC | DKEYP-99C4 | ZFIN Curated Data | |
| Encodes | EST | cb491 | Thisse et al., 2001 | |
| Encodes | EST | fb50f05 | ||
| Encodes | EST | fc22d09 | ||
| Encodes | EST | IMAGE:7158238 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001172370 (1) | 3510 nt | ||
| Genomic | GenBank:CR788285 (1) | 153408 nt | ||
| Polypeptide | UniProtKB:A0A8M3APP4 (1) | 1315 aa |
- Nemoz-Billet, L., Balland, M., Gilquin, L., Gillet, B., Stévant, I., Guillon, E., Hughes, S., Carpentier, G., Vaganay, E., Sohm, F., Misiak, V., Gonzalez-Melo, M.J., Koch, M., Ghavi-Helm, Y., Bretaud, S., Ruggiero, F. (2024) Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons. Proceedings of the National Academy of Sciences of the United States of America. 121:e2314588121e2314588121
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
- Schultz-Rogers, L.E., Thayer, M.L., Kambakam, S., Wierson, W.A., Helmer, J.A., Wishman, M.D., Wall, K.A., Greig, J.L., Forsman, J.L., Puchhalapalli, K., Nair, S., Weiss, T.J., Luiken, J.M., Blackburn, P.R., Ekker, S.C., Kool, M., McGrail, M. (2022) Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1267-1290
- Jin, M., Li, J., Hu, R., Xu, B., Huang, G., Huang, W., Chen, B., He, J., Cao, Y. (2021) Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 48(1):63-74
- Joshi, B., Wagh, G., Kaur, H., Patra, C. (2021) Zebrafish Model to Study Angiotensin II-Mediated Pathophysiology. Biology. 10(11):
- Angileri, K.M., Gross, J.M. (2020) dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye. Scientific Reports. 10:11293
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Mukherjee, D., Wagh, G., Mokalled, M.H., Kontarakis, Z., Dickson, A.L., Rayrikar, A., Günther, S., Poss, K.D., Stainier, D.Y.R., Patra, C. (2020) Ccn2a/Ctgfa is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. Development (Cambridge, England). 148(2):
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Li, G., Jin, D., Zhong, T.P. (2019) Tubgcp3 Is Required for Retinal Progenitor Cell Proliferation During Zebrafish Development. Frontiers in molecular neuroscience. 12:126
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