Gene
otulinb
- ID
- ZDB-GENE-070912-627
- Name
- OTU deubiquitinase with linear linkage specificity b
- Symbol
- otulinb Nomenclature History
- Previous Names
-
- fam105bb
- si:dkeyp-106c5.3
- wu:fc69a03
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 107 and otulipenia. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144154 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7501 | Allele with one point mutation | Unknown | Missense | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 107 | Alliance | {Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection} | 619986 |
| otulipenia | Alliance | Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive | 617099 |
| Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant | 621030 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FAM105 | Inactive ubiquitin thioesterase OTULINL |
|---|---|---|---|---|
| UniProtKB:A0A8M3B0B6 | InterPro | 349 | ||
| UniProtKB:A0A8M2BAN8 | InterPro | 409 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
otulinb-203
(1)
|
Ensembl | 661 nt | ||
| mRNA |
otulinb-204
(1)
|
Ensembl | 906 nt | ||
| mRNA |
otulinb-206
(1)
|
Ensembl | 1,761 nt | ||
| ncRNA |
otulinb-003
(1)
|
Ensembl | 817 nt | ||
| ncRNA |
otulinb-004
(1)
|
Ensembl | 904 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-106C5 | ZFIN Curated Data | |
| Encodes | EST | fc69a03 | ||
| Encodes | EST | IMAGE:7144154 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166015 (1) | 1761 nt | ||
| Genomic | GenBank:CR391940 (1) | 140400 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAN8 (1) | 409 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | OTULIN | 5 | Amino acid sequence comparison (1) |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Marandel, L., Labbe, C., Bobe, J., and Le Bail, P.Y. (2012) Evolutionary history of c-myc in teleosts and characterization of the duplicated c-myca genes in goldfish embryos. Molecular reproduction and development. 72(2):85-96
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