ZFIN is now using GRCz12tu for Genomic Data
Gene
otulinb
- ID
- ZDB-GENE-070912-627
- Name
- OTU deubiquitinase with linear linkage specificity b
- Symbol
- otulinb Nomenclature History
- Previous Names
-
- fam105bb
- si:dkeyp-106c5.3
- wu:fc69a03
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in innate immune response; negative regulation of inflammatory response; and regulation of tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant autoinflammation, panniculitis, and dermatosis syndrome; autosomal recessive autoinflammation, panniculitis, and dermatosis syndrome; and immunodeficiency 107. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144154 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant autoinflammation, panniculitis, and dermatosis syndrome | Alliance | Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant | 621030 |
| autosomal recessive autoinflammation, panniculitis, and dermatosis syndrome | Alliance | Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive | 617099 |
| immunodeficiency 107 | Alliance | {Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection} | 619986 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FAM105 | Inactive ubiquitin thioesterase OTULINL |
|---|---|---|---|---|
| UniProtKB:A0A8M3B0B6 | InterPro | 349 | ||
| UniProtKB:A0A8M2BAN8 | InterPro | 409 | ||
| UniProtKB:A0AC58G867 | InterPro | 409 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
otulinb-203
(1)
|
Ensembl | 661 nt | ||
| mRNA |
otulinb-204
(1)
|
Ensembl | 906 nt | ||
| mRNA |
otulinb-206
(1)
|
Ensembl | 1,761 nt | ||
| ncRNA |
otulinb-003
(1)
|
Ensembl | 817 nt | ||
| ncRNA |
otulinb-004
(1)
|
Ensembl | 904 nt | ||
| ncRNA |
otulinb-006
(1)
|
Ensembl | 764 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers