Gene
xirp1
- ID
- ZDB-GENE-050221-2
- Name
- xin actin binding repeat containing 1
- Symbol
- xirp1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Involved in retina layer formation. Acts upstream of or within glial cell development and retina development in camera-type eye. Located in adherens junction; desmosome; and intercalated disc. Is expressed in several structures, including adaxial cell; cardiovascular system; skeletal muscle; solid lens vesicle; and somite. Orthologous to human XIRP1 (xin actin binding repeat containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu717 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa46 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2039 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14052 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16645 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32918 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32919 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32920 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32921 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39826 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-xirp1 | Burger et al., 2016 | |
| CRISPR2-xirp1 | (2) | |
| CRISPR3-xirp1 | Charlton-Perkins et al., 2019 | |
| CRISPR4-xirp1 | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin-binding, Xin repeat | Xin actin-binding repeat-containing protein 1/2 |
|---|---|---|---|---|
| UniProtKB:Q5PZ43 | InterPro | 2297 | ||
| UniProtKB:A0A8M9PW88 | InterPro | 1735 | ||
| UniProtKB:A0A8M9Q8B1 | InterPro | 2548 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24C2 | ZFIN Curated Data | |
| Encodes | EST | eu717 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001012377 (1) | 7100 nt | ||
| Genomic | GenBank:BX649335 (1) | 220851 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q8B1 (1) | 2548 aa |
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X. (2018) Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Environmental science & technology. 52(14):7996-8004
- Burger, A., Lindsay, H., Felker, A., Hess, C., Anders, C., Chiavacci, E., Zaugg, J., Weber, L.M., Catena, R., Jinek, M., Robinson, M.D., Mosimann, C. (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development (Cambridge, England). 143(11):2025-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Otten, C., and Abdelilah-Seyfried, S. (2013) Laser-inflicted Injury of Zebrafish Embryonic Skeletal Muscle. Journal of visualized experiments : JoVE. (71):e4351
- Otten, C., van der Ven, P.F., Lewrenz, I., Paul, S., Steinhagen, A., Busch-Nentwich, E., Eichhorst, J., Wiesner, B., Stemple, D., Strähle, U., Fürst, D.O., and Abdelilah-Seyfried, S. (2012) Xirp proteins mark injured skeletal muscle in zebrafish. PLoS One. 7(2):e31041
- Grosskurth, S.E., Bhattacharya, D., Wang, Q., and Lin, J.J. (2008) Emergence of Xin demarcates a key innovation in heart evolution. PLoS One. 3(8):e2857
- Lange, M., Kaynak, B., Forster, U.B., Tönjes, M., Fischer, J.J., Grimm, C., Schlesinger, J., Just, S., Dunkel, I., Krueger, T., Mebus, S., Lehrach, H., Lurz, R., Gobom, J., Rottbauer, W., Abdelilah-Seyfried, S., and Sperling, S. (2008) Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes & Development. 22(17):2370-2384
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