Gene
ghsra
- ID
- ZDB-GENE-070912-238
- Name
- growth hormone secretagogue receptor a
- Symbol
- ghsra Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable growth hormone secretagogue receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to act upstream of or within signal transduction. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including brain; brainstem and spinal white matter; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Growth hormone deficiency, isolated partial | 615925 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Growth hormone secretagogue receptor/motilin receptor |
|---|---|---|---|---|---|
| UniProtKB:B0V1I9 | InterPro | 360 |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244M8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001146272 (1) | 1083 nt | ||
| Genomic | GenBank:CR848726 (1) | 155462 nt | ||
| Polypeptide | UniProtKB:B0V1I9 (1) | 360 aa |
- Fei, Y., Bao, Z., Wang, Q., Zhu, Y., Lu, J., Ouyang, L., Hu, Q., Zhou, Y., Chen, L. (2024) CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism. General and comparative endocrinology. 355:114563
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Kowatschew, D., Korsching, S.I. (2021) An ancient adenosine receptor gains olfactory function in bony vertebrates. Genome biology and evolution. 13(9)
- Rajeswari, J.J., Blanco, A.M., Unniappan, S. (2020) Phoenixin-20 (PNX-20) Suppresses Food Intake, Modulates Glucoregulatory Enzymes, and Enhances Glycolysis in Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 318(5):R917-R928
- Zhang, L., Song, J., Zang, Z., Tang, H., Li, W., Lai, S., Deng, C. (2020) Adaptive evolution of GPR39 in diverse directions in vertebrates. General and comparative endocrinology. 299:113610
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Opazo, R., Plaza-Parrochia, F., Cardoso Dos Santos, G.R., Carneiro, G.R.A., Sardela, V.F., Romero, J., Valladares, L. (2019) Fasting Upregulates npy, agrp, and ghsr Without Increasing Ghrelin Levels in Zebrafish (Danio rerio) Larvae. Frontiers in Physiology. 9:1901
- Navarro-Guillén, C., Dias, J., Rocha, F., Castanheira, M.F., Martins, C.I.M., Laizé, V., Gavaia, P.J., Engrola, S. (2018) Does a ghrelin stimulus during zebrafish embryonic stage modulate its performance on the long-term?. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 228:1-8
- Cui, Y., Lv, S., Liu, J., Nie, S., Chen, J., Dong, Q., Huang, C., Yang, D. (2017) Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Human & Experimental Toxicology. 36(3):207-217
- Cai, W.J., Yuan, X.C., Yuan, Y.C., Xie, S.Q., Gong, Y., Su, H., Qiao, Y. (2015) Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 179:54-61
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