Gene
smyhc2
- ID
- ZDB-GENE-070822-12
- Name
- slow myosin heavy chain 2
- Symbol
- smyhc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in slow-twitch skeletal muscle fiber contraction. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Is expressed in esophagus and musculature system. Orthologous to human MYH6 (myosin heavy chain 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA repair protein XRCC4-like, C-terminal | Kinesin motor domain superfamily | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QE01
|
278 | ||||||
|
UniProtKB:A0A0N4SU68
|
1938 | ||||||
|
UniProtKB:A0A0N4SUF4
|
1940 | ||||||
|
UniProtKB:B6IDE1
|
1939 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
smyhc2-202
(1)
|
Ensembl | 6,027 nt | ||
| mRNA |
smyhc2-203
(1)
|
Ensembl | 5,896 nt | ||
| mRNA |
smyhc2-204
(1)
|
Ensembl | 970 nt |
Interactions and Pathways
No data available
Plasmids
No data available