Gene

smyhc2

ID
ZDB-GENE-070822-12
Name
slow myosin heavy chain 2
Symbol
smyhc2 Nomenclature History
Previous Names
  • MYH7 (1)
  • zgc:171631 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Is predicted to enable ATP binding activity; actin filament binding activity; and motor activity. Acts upstream of or within slow-twitch skeletal muscle fiber contraction. Predicted to be part of myosin complex. Is expressed in esophagus and musculature system. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smyhc2 Human Ortholog
No data available
Associated With smyhc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QE01 278
UniProtKB:A0A0N4SU68 1938
UniProtKB:A0A0N4SUF4 1940
UniProtKB:B6IDE1 1939
UniProtKB:A0A0G2L6C1 1939
UniProtKB:A0A0N4STT5 2008
UniProtKB:B2LLJ4 82
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations