Gene
f2rl1.2
- ID
- ZDB-GENE-070615-24
- Name
- coagulation factor II (thrombin) receptor-like 1, tandem duplicate 2
- Symbol
- f2rl1.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables proteinase-activated receptor activity. Acts upstream of or within with a negative effect on cell population proliferation. Acts upstream of or within morphogenesis of an epithelium. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in digestive system; notochord; otic vesicle; pronephric duct; and thrombocyte. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schepis et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fr57 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| la022091Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sfc18b | Allele with multiple variants | Unknown | Unknown | TALEN | |
| sfc21 | Allele with multiple variants | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-f2rl1.2 | Hatzold et al., 2023 | |
| MO1-f2rl1.2 | N/A | Schepis et al., 2018 |
| MO2-f2rl1.2 | N/A | (3) |
| TALEN1-f2rl1.2 | (2) | |
| TALEN2-f2rl1.2 | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Protease-activated receptor | Protease-activated receptor 2 |
|---|---|---|---|---|---|
|
UniProtKB:I3IRY7
|
390 | ||||
|
UniProtKB:A5PLC2
|
389 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
f2rl1.2-201
(1)
|
Ensembl | 1,486 nt | ||
| mRNA |
f2rl1.2-202
(1)
|
Ensembl | 1,493 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(tp63:f2rl1.2-EGFP) |
|
| 1 | Hatzold et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-163M14 | ||
| Encodes | cDNA | MGC:165523 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098778 (1) | 1510 nt | ||
| Genomic | GenBank:BX323555 (2) | 180416 nt | ||
| Polypeptide | UniProtKB:I3IRY7 (1) | 390 aa |
- Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
- Hatzold, J., Wessendorf, H., Pogoda, H.M., Bloch, W., Hammerschmidt, M. (2021) The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Developmental Biology. 476:148-170
- Armistead, J., Hatzold, J., van Roye, A., Fahle, E., Hammerschmidt, M. (2020) Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. The Journal of cell biology. 219(2):
- Schepis, A., Barker, A., Srinivasan, Y., Balouch, E., Zheng, Y., Lam, I., Clay, H., Hsiao, C.D., Coughlin, S.R. (2018) Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. The Journal of cell biology. 217(3):1097-1112
- Pereiro, P., Forn-Cuní, G., Dios, S., Coll, J., Figueras, A., Novoa, B. (2017) Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. Antiviral Research. 145:146-159
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Xu, H., Echemendia, N., Chen, S., and Lin, F. (2011) Identification and expression patterns of members of the protease-activated receptor (par) gene family during zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(1):278-287
- Kim, S., Carrillo, M., Kulkarni, V., and Jagadeeswaran, P. (2009) Evolution of primary hemostasis in early vertebrates. PLoS One. 4(12):e8403
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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