ZFIN is now using GRCz12tu for Genomic Data
Gene
ptpro
- ID
- ZDB-GENE-070424-54
- Name
- protein tyrosine phosphatase receptor type O
- Symbol
- ptpro Nomenclature History
- Previous Names
-
- zgc:158179
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Wnt-protein binding activity; cadherin binding activity; and protein tyrosine phosphatase activity. Acts upstream of or within cerebellum morphogenesis and regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and plasma membrane. Is expressed in several structures, including brain; eye; optic cup; optic vesicle; and tail bud. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Liao et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 6 | Alliance | Nephrotic syndrome, type 6 | 614196 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Family | IPR042996 | Receptor-type tyrosine-protein phosphatase O |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like domain | Immunoglobulin-like fold | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Receptor-type tyrosine-protein phosphatase O | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4IFW3 | InterPro | 1238 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers