Gene
npvf
- ID
- ZDB-GENE-070424-226
- Name
- neuropeptide VF precursor
- Symbol
- npvf Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within negative regulation of luteinizing hormone secretion and positive regulation of circadian sleep/wake cycle, sleep. Predicted to be located in extracellular region. Is expressed in brain; female organism; gonad; and male organism. Orthologous to human NPVF (neuropeptide VF precursor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lee et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct845 | Allele with one deletion | Unknown | Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026297 | FMRFamide-related peptide/Growth hormone-releasing peptide |
Domain Details Per Protein
| Protein | Additional Resources | Length | FMRFamide-related peptide/Growth hormone-releasing peptide |
|---|---|---|---|
| UniProtKB:Q1LW92 | InterPro | 198 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(npvf:EGFP) |
|
| 1 | Madelaine et al., 2017 | |
| Tg(hsp70l:npvf) |
|
| 1 | (2) | |
| Tg(hsp70l:npvf-RFRP1) |
|
| 1 | (2) | |
| Tg(hsp70l:npvf-RFRP1,2) |
|
| 1 | (2) | |
| Tg(hsp70l:npvf-RFRP1,3) |
|
| 1 | (2) | |
| Tg(hsp70l:npvf-RFRP2) |
|
| 1 | (2) | |
| Tg(hsp70l:npvf-RFRP2,3) |
|
| 1 | (2) | |
| Tg(hsp70l:npvf-RFRP3) |
|
| 1 | (2) | |
| Tg(npvf:C1V1-mCherry) |
|
| 1 | Madelaine et al., 2017 | |
| Tg(npvf:EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-22M8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195091 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195095 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082949 (1) | 1233 nt | ||
| Genomic | GenBank:BX640464 (1) | 255824 nt | ||
| Polypeptide | UniProtKB:Q1LW92 (1) | 198 aa |
- Sagi, D., Tibi, M., Admati, I., Lerer-Goldshtein, T., Hochgerner, H., Zeisel, A., Appelbaum, L. (2024) Single-cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(36):
- Rodrigues, M.S., Tovo-Neto, A., Rosa, I.F., Doretto, L.B., Fallah, H.P., Habibi, H.R., Nóbrega, R.H. (2022) Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and-Gonadal Axes in Zebrafish. Frontiers in cell and developmental biology. 10:865948
- Rodrigues, M.S., Fallah, H.P., Zanardini, M., Malafaia, G., Habibi, H.R., Nóbrega, R.H. (2021) Interaction between thyroid hormones and gonadotropin inhibitory hormone in ex vivo culture of zebrafish testis: an approach to study multifactorial control of spermatogenesis. Molecular and Cellular Endocrinology. 532:111331
- Song, Y., Peng, W., Luo, J., Zhu, Z., Hu, W. (2021) Organization of the gonadotropin-inhibitory hormone (Lpxrfa) system in the brain of zebrafish (Danio rerio). General and comparative endocrinology. 304:113722
- Chen, Q., Jingjing, A., Xie, D., Gong, S., Lian, X., Liu, Z., Shen, Y., Li, Y. (2020) Suppression and recovery of reproductive behavior induced by early life exposure to mercury in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 239:108876
- Fallah, H.P., Habibi, H.R. (2020) Role of GnRH and GnIH in paracrine/autocrine control of final oocyte maturation. General and comparative endocrinology. 299:113619
- Fallah, H.P., Rodrigues, M.S., Zanardini, M., Nóbrega, R.H., Habibi, H.R. (2020) Effects of gonadotropin-inhibitory hormone on early and late stages of spermatogenesis in ex-vivo culture of zebrafish testis. Molecular and Cellular Endocrinology. 520:111087
- Lee, D.A., Oikonomou, G., Cammidge, T., Andreev, A., Hong, Y., Hurley, H., Prober, D.A. (2020) Neuropeptide VF neurons promote sleep via the serotonergic raphe. eLIFE. 9:
- Lovett-Barron, M., Chen, R., Bradbury, S., Andalman, A.S., Wagle, M., Guo, S., Deisseroth, K. (2020) Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nature Neuroscience. 23(8):959-967
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
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