Gene
mhc2dab
- ID
- ZDB-GENE-980526-200
- Name
- major histocompatibility complex class II DAB gene
- Symbol
- mhc2dab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DOB (major histocompatibility complex, class II, DO beta); HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); and HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000353 | MHC class II, beta chain, N-terminal |
| Domain | IPR003597 | Immunoglobulin C1-set |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Family | IPR050160 | Major Histocompatibility Complex/Immunoglobulin |
| Homologous_superfamily | IPR011162 | MHC classes I/II-like antigen recognition protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014745 | MHC class II, alpha/beta chain, N-terminal |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin C1-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Major Histocompatibility Complex/Immunoglobulin | MHC classes I/II-like antigen recognition protein | MHC class II, alpha/beta chain, N-terminal | MHC class II, beta chain, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1MTC8 | InterPro | 250 | ||||||||
| UniProtKB:Q8MGW8 | InterPro | 250 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mhc2dab-201
(1)
|
Ensembl | 1,428 nt |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mhc2dab:EGFP) |
|
| 1 | (13) | |
| Tg(mhc2dab:mCherry) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-2H4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123077 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152682 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158870 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC110097 (1) | 1465 nt | ||
| Genomic | GenBank:AL928944 (1) | 55565 nt | ||
| Polypeptide | UniProtKB:Q1MTC8 (1) | 250 aa |
No data available
- McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Limonta, G., Mancia, A., Abelli, L., Fossi, M.C., Caliani, I., Panti, C. (2021) Effects of microplastics on head kidney gene expression and enzymatic biomarkers in adult zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 245:109037
- Ma, H., Liu, Z., Yang, Y., Feng, D., Dong, Y., Garbutt, T.A., Hu, Z., Wang, L., Luan, C., Cooper, C.D., Li, Y., Welch, J.D., Qian, L., Liu, J. (2021) Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration. EMBO reports. 22(11):e52901
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., Sung, Y.Y. (2020) Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Zebrafish. 17:91-103
- Shao, X., Fu, Y., Ma, J., Li, X., Lu, C., Zhang, R. (2020) Functional alterations and transcriptomic changes during zebrafish cardiac aging. Biogerontology. 21(5):637-652
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