Gene

nrxn2a

ID

ZDB-GENE-070206-5

Name

neurexin 2a

Symbol

nrxn2a Nomenclature History

Previous Names

nrxn2aa
nrxn2ab

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Acts upstream of or within axon extension involved in axon guidance; chemical synaptic transmission; and motor neuron axon guidance. Predicted to be located in membrane. Is expressed in nervous system and spinal cord neural tube. Orthologous to human NRXN2 (neurexin 2).

Genome Resources

Note

nrxn2a has two isoforms, alpha (DQ641428) and beta (DQ641429)

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrxn2a Human Ortholog

No data available

Associated With nrxn2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR003585	Neurexin/syndecan/glycophorin C
Domain	IPR027789	Syndecan/Neurexin domain
Family	IPR050372	Neurexin-related cell adhesion and synaptic protein
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like domain	Laminin G domain	Neurexin-related cell adhesion and synaptic protein	Neurexin/syndecan/glycophorin C	Syndecan/Neurexin domain
UniProtKB:A0A8M9P3C3 InterPro	1658
UniProtKB:A0A8M9PIB5 InterPro	1638
UniProtKB:A0A8M9P3C5 InterPro	1468
UniProtKB:A0A8M3AU05 InterPro	1652
UniProtKB:A1XQX4 InterPro	1670
UniProtKB:A0A8M9PTX2 InterPro	1508
UniProtKB:A0A8M9PQH6 InterPro	1659
UniProtKB:A0A8M9PTW7 InterPro	1667
UniProtKB:A0A8M9PIB8 InterPro	458
UniProtKB:A0A8M3ALL4 InterPro	1492
UniProtKB:A0A8M9PQI0 InterPro	1478
UniProtKB:A0A8M9PIB2 InterPro	1668
UniProtKB:A0A8M9PCQ2 InterPro	1453
UniProtKB:A0A8M9PCQ0 InterPro	1645
UniProtKB:A0A8M3AMB4 InterPro	618
UniProtKB:B7ZCV1 InterPro	648
UniProtKB:A0A8M2B8E6 InterPro	488
UniProtKB:A0A8M3AWZ3 InterPro	1660

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nrxn2a-201 (1) Ensembl	Ensembl	4,333 nt	Select Tool ZFIN BLAST
mRNA	nrxn2a-203 (1) Ensembl	Ensembl	6,930 nt	Select Tool ZFIN BLAST
mRNA	nrxn2a-204 (1) Ensembl	Ensembl	5,013 nt	Select Tool ZFIN BLAST
ncRNA	nrxn2a-003 (1) Ensembl	Ensembl	576 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations