ZFIN ID: ZDB-GENE-070119-4
Gene Name: BCL2 binding component 3
Gene Symbol: bbc3    Nomenclature History

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Previous Name: Puma (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Involved in cellular response to ionizing radiation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to the mitochondrion. Is expressed in several structures, including central nervous system; head; heart; male organism; and pleuroperitoneal region. Orthologous to human BBC3 (BCL2 binding component 3).
Genome Resources: Alliance (1),  Gene:751763 (1),  Ensembl(GRCz11):ENSDARG00000069282 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb288 Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb289 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • la027618Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-bbc3 1
    MO1-bbc3 N/A 2
    MO2-bbc3 N/A 4
    TALEN1-bbc3
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH bbc3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH bbc3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of apoptotic process (more)
    Cellular Component mitochondrion (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR031661 Bcl-2-binding component 3
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bbc3-201 (1)    Ensembl 3808
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM bbc3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(5xUAS:bbc3,5xUAS:Hsa.HIST1H2BJ-Citrine,cryaa:RFP) cryaa bbc3CitrineRFP Danio rerioHomo sapiens 1 2
    Tg(kop:LOXP-SV40-LOXP-bbc3-UTR-nanos3,CMV:EGFP) CMVkop bbc3EGFPnanos3 Danio rerio 1 2
    Tg(UAS:bbc3-UTR-nanos3,CMV:EGFP) CMVUAS bbc3EGFPnanos3 Danio rerio 1 3
    MARKER RELATIONSHIPS
    bbc3 Contained in: [BAC] CH211-167J9 (1), DKEY-31M14 (order this)
    bbc3 Encodes: [cDNA] MGC:161994 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045472 (1) 3791 nt
    Genomic GenBank:CR855332 (1) 212455 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QKA1 (1) 181 aa
    Sequence Information (all 15)
    ORTHOLOGY for bbc3 ( Chr: 15 )
    CITATIONS (96)