Gene
ptgis
- ID
- ZDB-GENE-070116-1
- Name
- prostaglandin I2 (prostacyclin) synthase
- Symbol
- ptgis Nomenclature History
- Previous Names
-
- ptgisl
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Exhibits heme binding activity and prostaglandin-I synthase activity. Involved in prostaglandin biosynthetic process. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yeh et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | Hypertension, essential | 145500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cytochrome P450, E-class, group IV | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:F1RE08
|
480 |
Interactions and Pathways
No data available
Plasmids
No data available