Gene

bcl11ba

ID

ZDB-GENE-061207-62

Name

BCL11 transcription factor B a

Symbol

bcl11ba Nomenclature History

Previous Names

bcl11b.1 (1)
bcl11b
si:dkey-238i13.1
wu:fj43a03
zgc:165628 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of SWI/SNF complex. Predicted to be active in nucleus. Is expressed in thymus. Human ortholog(s) of this gene implicated in immunodeficiency 49. Orthologous to human BCL11B (BCL11 transcription factor B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcl11ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 49	Alliance	Immunodeficiency 49, severe combined	617237
		Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities	618092

Associated With bcl11ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR056438	CTCF-like, C2H2 zinc finger
Family	IPR051497	Developmental and Hematopoietic Transcription Factors
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A2R8Q8A6	InterPro	814
UniProtKB:A0A8M3AR85	InterPro	813
UniProtKB:X1WBZ3	InterPro	776

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	bcl11ba-202 (1) Ensembl	Ensembl	1,065 nt	Select Tool ZFIN BLAST
mRNA	bcl11ba-203 (1) Ensembl	Ensembl	3,240 nt	Select Tool ZFIN BLAST
mRNA	bcl11ba-204 (1) Ensembl	Ensembl	6,099 nt	Select Tool ZFIN BLAST
mRNA	bcl11ba-205 (1) Ensembl	Ensembl	8,016 nt	Select Tool ZFIN BLAST
ncRNA	bcl11ba-003 (1) Ensembl	Ensembl	543 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations