Gene
cenpe
- ID
- ZDB-GENE-060929-860
- Name
- centromere protein E
- Symbol
- cenpe Nomenclature History
- Previous Names
-
- wu:fc06a10
- zgc:152925 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Predicted to be involved in microtubule-based movement and mitotic cell cycle. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Yu et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19390 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24832 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32570 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32571 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko13a | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 13 | Alliance | ?Microcephaly 13, primary, autosomal recessive | 616051 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YXU4 | InterPro | 2352 | |||||
| UniProtKB:A0A8M2BFG2 | InterPro | 2668 | |||||
| UniProtKB:E7F2U4 | InterPro | 2690 | |||||
| UniProtKB:A0A8M2BFG4 | InterPro | 2626 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-129C2 | ZFIN Curated Data | |
| Encodes | EST | fc06a10 | ||
| Encodes | cDNA | MGC:152925 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327759 (1) | 8496 nt | ||
| Genomic | GenBank:CU179747 (1) | 162432 nt | ||
| Polypeptide | UniProtKB:E7F2U4 (1) | 2690 aa |
- Lin, X., Liu, F., Meng, K., Liu, H., Zhao, Y., Chen, Y., Hu, W., Luo, D. (2022) Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Life (Basel, Switzerland). 12(9)
- Chen, J., Li, G., Lian, J., Ma, N., Huang, Z., Li, J., Wen, Z., Zhang, W., Zhang, Y. (2021) Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Science China. Life sciences. 64(12):2186-2201
- Yu, K.W., She, Z.Y., Wei, Y.L., Zhong, N. (2020) Kinesin-7 CENP-E regulates cell division, gastrulation and organogenesis in development. European journal of cell biology. 99:151107
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Castro, L.F., Gonçalves, O., Mazan, S., Tay, B.H., Venkatesh, B., Wilson, J.M. (2013) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Proceedings. Biological sciences. 281:20132669
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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