Gene
cenpe
- ID
- ZDB-GENE-060929-860
- Name
- centromere protein E
- Symbol
- cenpe Nomenclature History
- Previous Names
-
- wu:fc06a10
- zgc:152925 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity. Predicted to be involved in microtubule-based movement and mitotic cell cycle. Predicted to be located in condensed chromosome, centromeric region; cytoplasm; and cytoskeleton. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Yu et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa19390 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa24832 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32570 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa32571 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zko13a | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
primary autosomal recessive microcephaly 13 | Alliance | ?Microcephaly 13, primary, autosomal recessive | 616051 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
Domain | IPR001752 | Kinesin motor domain |
Family | IPR027640 | Kinesin-like protein |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M6YXU4 | InterPro | 2352 | |||||
UniProtKB:A0A8M2BFG2 | InterPro | 2668 | |||||
UniProtKB:E7F2U4 | InterPro | 2690 | |||||
UniProtKB:A0A8M2BFG4 | InterPro | 2626 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-129C2 | ZFIN Curated Data | |
Encodes | EST | fc06a10 | ||
Encodes | cDNA | MGC:152925 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001327759 (1) | 8496 nt | ||
Genomic | GenBank:CU179747 (1) | 162432 nt | ||
Polypeptide | UniProtKB:E7F2U4 (1) | 2690 aa |
- Lin, X., Liu, F., Meng, K., Liu, H., Zhao, Y., Chen, Y., Hu, W., Luo, D. (2022) Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Life (Basel, Switzerland). 12(9)
- Chen, J., Li, G., Lian, J., Ma, N., Huang, Z., Li, J., Wen, Z., Zhang, W., Zhang, Y. (2021) Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Science China. Life sciences. 64(12):2186-2201
- Yu, K.W., She, Z.Y., Wei, Y.L., Zhong, N. (2020) Kinesin-7 CENP-E regulates cell division, gastrulation and organogenesis in development. European journal of cell biology. 99:151107
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Castro, L.F., Gonçalves, O., Mazan, S., Tay, B.H., Venkatesh, B., Wilson, J.M. (2013) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Proceedings. Biological sciences. 281:20132669
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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