Gene

manf

ID
ZDB-GENE-060929-640
Name
mesencephalic astrocyte-derived neurotrophic factor
Symbol
manf Nomenclature History
Previous Names
  • im:6909481
  • zgc:153327
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have growth factor activity. Involved in dopaminergic neuron differentiation. Predicted to localize to endoplasmic reticulum and extracellular space. Is expressed in several structures, including axis; brain; hatching gland; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in breast cancer; lung non-small cell carcinoma; pancreatic cancer; renal cell carcinoma; and squamous cell carcinoma. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Chen et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With manf Human Ortholog
No data available
Associated With manf Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR019345 Armet protein
Homologous_superfamily IPR036361 SAP domain superfamily
Domain Details Per Protein
Protein Length Armet protein SAP domain superfamily
UniProtKB:Q08CA7 180
UniProtKB:F1QDQ5 180
UniProtKB:A0A0B5JF91 180
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-manf polyclonal IgG Rabbit
  • IHC
  • WB
ProSci Incorporated
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations