Gene
crcp
- ID
- ZDB-GENE-060825-150
- Name
- calcitonin gene-related peptide-receptor component protein
- Symbol
- crcp Nomenclature History
- Previous Names
-
- rcp9
- zgc:153737
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable nucleotide binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in blastomere and hematopoietic system. Orthologous to human CRCP (CGRP receptor component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Wei et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Wei et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hkz8 | Allele with one point mutation | Exon 2 | Premature Stop | ENU | |
| la021966Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23980 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006590 | RNA polymerase Rpb4/RPC9, core |
| Family | IPR005574 | RNA polymerase subunit Rpb4/RPC9 |
| Family | IPR038846 | DNA-directed RNA polymerase III subunit RPC9 |
| Homologous_superfamily | IPR010997 | HRDC-like superfamily |
| Homologous_superfamily | IPR038324 | Rpb4/RPC9 superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-directed RNA polymerase III subunit RPC9 | HRDC-like superfamily | RNA polymerase Rpb4/RPC9, core | RNA polymerase subunit Rpb4/RPC9 | Rpb4/RPC9 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NAV1 | InterPro | 144 | |||||
| UniProtKB:A0A8M9PIF8 | InterPro | 135 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-225F3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153737 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191763 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045373 (1) | 667 nt | ||
| Genomic | GenBank:CR450753 (2) | 160631 nt | ||
| Polypeptide | UniProtKB:A0A8M1NAV1 (1) | 144 aa |
- Wei, Y., Xu, J., Zhang, W., Wen, Z., Liu, F. (2016) RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development (Cambridge, England). 143(12):2103-10
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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