Gene

wdr4

ID

ZDB-GENE-060810-10

Name

WD repeat domain 4

Symbol

wdr4 Nomenclature History

Previous Names

im:6900357
si:ch211-140m22.6

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to contribute to tRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in tRNA modification. Predicted to localize to cytosol; nucleus; and tRNA methyltransferase complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human WDR4 (WD repeat domain 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6900357 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdr4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
microcephaly, growth deficiency, seizures, and brain malformations	Alliance	Microcephaly, growth deficiency, seizures, and brain malformations	618346
		Galloway-Mowat syndrome 6	618347

Associated With wdr4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR028884	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat