Gene

wdr4

ID
ZDB-GENE-060810-10
Name
WD repeat domain 4
Symbol
wdr4 Nomenclature History
Previous Names
  • im:6900357
  • si:ch211-140m22.6
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Is predicted to contribute to tRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in tRNA modification. Predicted to localize to cytosol; nucleus; and tRNA methyltransferase complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human WDR4 (WD repeat domain 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wdr4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Galloway-Mowat syndrome 6 618347
Microcephaly, growth deficiency, seizures, and brain malformations 618346
Associated With wdr4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017986 WD40-repeat-containing domain
Family IPR028884 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Domain Details Per Protein
Protein Length tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WD40 repeat WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:E7EZ59 413
UniProtKB:A4IGH4 413
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations