Gene
slc39a5
- ID
- ZDB-GENE-060608-1
- Name
- solute carrier family 39 member 5
- Symbol
- slc39a5 Nomenclature History
- Previous Names
-
- wu:fc74g12
- ZIP5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable monoatomic cation:bicarbonate symporter activity and zinc ion transmembrane transporter activity. Acts upstream of or within angiogenesis and intracellular zinc ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in gut and head. Human ortholog(s) of this gene implicated in myopia. Orthologous to human SLC39A5 (solute carrier family 39 member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Xia et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12403 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29976 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37758 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44023 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zju30 | Allele with one insertion | Exon 5 | Frameshift, Premature Stop | CRISPR | |
| zju31 | Allele with one deletion | Exon 5 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc39a5 | Xia et al., 2020 | |
| MO1-slc39a5 | N/A | Xia et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc/iron permease | Zinc Iron Protein (ZIP) Transporter |
|---|---|---|---|---|
| UniProtKB:A0A2R8Q6G1 | InterPro | 583 | ||
| UniProtKB:A0A8N7TDT7 | InterPro | 610 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc39a5-201
(1)
|
Ensembl | 2,252 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-66I15 | ZFIN Curated Data | |
| Encodes | EST | fc74g12 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021473734 (1) | 2254 nt | ||
| Genomic | GenBank:BX957355 (1) | 155581 nt | ||
| Polypeptide | UniProtKB:A0A8N7TDT7 (1) | 610 aa |
- He, X., Ge, C., Xia, J., Xia, Z., Zhao, L., Huang, S., Wang, R., Pan, J., Cheng, T., Xu, P.F., Wang, F., Min, J. (2023) The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 10(17):e2205345
- Xia, Z., Bi, X., Lian, J., Dai, W., He, X., Zhao, L., Min, J., Wang, F. (2020) Slc39a5-mediated zinc homeostasis plays an essential role in venous angiogenesis in zebrafish. Open Biology. 10:200281
- Zhao, L., Tan, J., Li, D., Jiang, L., Li, T., Yang, Y., Wang, G., Shang, Z., Wang, J., Zhou, J. (2019) SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Biochemical and Biophysical Research Communications. 511(4):896-902
- Yan, G., Zhang, Y., Yu, J., Yu, Y., Zhang, F., Zhang, Z., Wu, A., Yan, X., Zhou, Y., and Wang, F. (2012) Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish. PLoS One. 7(8):e42939
- Kambe, T., Suzuki, T., Nagao, M., and Yamaguchi-Iwai, Y. (2006) Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters. Genomics, proteomics & bioinformatics. 4(1):1-9
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