Gene
fras1
- ID
- ZDB-GENE-060526-68
- Name
- Fraser extracellular matrix complex subunit 1
- Symbol
- fras1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including basement membrane organization; embryonic viscerocranium morphogenesis; and epithelial structure maintenance. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including median fin fold; mesoderm; nervous system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159429 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1048 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| b1130 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la025056Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025057Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0156Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14516 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17510 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20491 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20492 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20493 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fras1 | Zhang et al., 2024 | |
| MO1-fras1 | N/A | Carney et al., 2010 |
| MO2-fras1 | N/A | Carney et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fraser syndrome 1 | Alliance | Fraser syndrome 1 | 219000 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CalX-like domain superfamily | CSPG repeat | EGF-like domain | FRAS1-related extracellular matrix | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Na-Ca exchanger/integrin-beta4 | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q633
|
3970 | ||||||||
|
UniProtKB:A0A8M9Q8W1
|
3992 | ||||||||
|
UniProtKB:A0A8M3AZT2
|
4002 | ||||||||
|
UniProtKB:A0A0R4IQJ3
|
4003 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-132F12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-191A6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-29B15 | ZFIN Curated Data | |
| Encodes | EST | fc10b09 | ||
| Encodes | EST | ibd5080 | ||
| Encodes | EST | IMAGE:7159429 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130840 (1) | 13101 nt | ||
| Genomic | GenBank:BX571800 (2) | 195520 nt | ||
| Polypeptide | UniProtKB:A0A0R4IQJ3 (1) | 4003 aa |
- Benard, E.L., Küçükaylak, I., Hatzold, J., Berendes, K.U.W., Carney, T.J., Beleggia, F., Hammerschmidt, M. (2023) wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(6):566-592
- Mahabaleshwar, H., Asharani, P.V., Loo, T.Y., Koh, S.Y., Pitman, M.R., Kwok, S., Ma, J., Hu, B., Lin, F., Li Lok, X., Pitson, S.M., Saunders, T.E., Carney, T.J. (2022) Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports. 23(8):e54464
- Kimmel, C.B., Wind, A.L., Oliva, W., Ahlquist, S.D., Walker, C., Dowd, J., Blanco-Sánchez, B., Titus, T.A., Batzel, P., Talbot, J.C., Postlethwait, J.H., Nichols, J.T. (2020) Transgene-mediated skeletal phenotypic variation in zebrafish. Journal of Fish Biology. 98(4):956-970
- Statzer, C., Ewald, C.Y. (2020) The extracellular matrix phenome across species. Matrix biology plus. 8:100039
- Liedtke, D., Orth, M., Meissler, M., Geuer, S., Knaup, S., Köblitz, I., Klopocki, E. (2019) ECM alterations in Fndc3a (Fibronectin Domain Containing Protein 3A) deficient zebrafish cause temporal fin development and regeneration defects. Scientific Reports. 9:13383
- Tian, J., Shao, J., Liu, C., Hou, H.Y., Chou, C.W., Shboul, M., Li, G.Q., El-Khateeb, M., Samarah, O.Q., Kou, Y., Chen, Y.H., Chen, M.J., Lyu, Z., Chen, W.L., Chen, Y.F., Sun, Y.H., Liu, Y.W. (2018) Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development. Cellular and molecular life sciences : CMLS. 76(1):163-178
- Talbot, J.C., Nichols, J.T., Yan, Y.L., Leonard, I.F., BreMiller, R.A., Amacher, S.L., Postlethwait, J.H., Kimmel, C.B. (2016) Pharyngeal morphogenesis requires fras1-itga8- dependent epithelial-mesenchymal interaction. Developmental Biology. 416(1):136-48
- Nagendran, M., Arora, P., Gori, P., Mulay, A., Ray, S., Jacob, T., Sonawane, M. (2015) Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Development (Cambridge, England). 142(2):320-30
- Westcot, S.E., Hatzold, J., Urban, M.D., Richetti, S.K., Skuster, K.J., Harm, R.M., Lopez Cervera, R., Umemoto, N., McNulty, M.S., Clark, K.J., Hammerschmidt, M., Ekker, S.C. (2015) Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS One. 10:e0130688
- Richardson, R.J., Gebauer, J.M., Zhang, J.L., Kobbe, B., Keene, D.R., Karlsen, K.R., Richetti, S., Wohl, A.P., Sengle, G., Neiss, W.F., Paulsson, M., Hammerschmidt, M., and Wagener, R. (2014) AMACO Is a Component of the Basement Membrane-Associated Fraser Complex. The Journal of investigative dermatology. 134(5):1313-22
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