Gene

fras1

ID
ZDB-GENE-060526-68
Name
Fraser extracellular matrix complex subunit 1
Symbol
fras1 Nomenclature History
Previous Names
  • id:ibd5080
  • pif (1)
  • pinfin (1)
  • si:ch211-191a6.5
  • wu:fc10b09
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Involved in several processes, including basement membrane organization; embryonic viscerocranium morphogenesis; and epithelial structure maintenance. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Is expressed in several structures, including epithelium; mesoderm; nervous system; pharyngeal arch; and trunk. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fras1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fraser syndrome 1 Alliance Fraser syndrome 1 219000
Associated With fras1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR003644 Na-Ca exchanger/integrin-beta4
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR038081 CalX-like domain superfamily
Repeat IPR006212 Furin-like repeat
Repeat IPR039005 CSPG repeat
Domain Details Per Protein
Protein Length CalX-like domain superfamily CSPG repeat EGF-like domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Na-Ca exchanger/integrin-beta4 VWFC domain
UniProtKB:F1Q633 3970
UniProtKB:A0A0R4IQJ3 4003
UniProtKB:D7PS88 4003
UniProtKB:A0A2R8QFB7 3977
UniProtKB:A0A2R8QDV4 3961
UniProtKB:B6IDE3 3989
UniProtKB:A0A2R8Q1V0 3997
UniProtKB:A2BHG4 3936
UniProtKB:A0A2R8QSM6 3978
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fras1 polyclonal Rabbit
  • IHC
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations