Gene

fras1

ID
ZDB-GENE-060526-68
Name
Fraser extracellular matrix complex subunit 1
Symbol
fras1 Nomenclature History
Previous Names
  • id:ibd5080
  • pif (1)
  • pinfin (1)
  • si:ch211-191a6.5
  • wu:fc10b09
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Involved in several processes, including basement membrane organization; embryonic viscerocranium morphogenesis; and epithelial structure maintenance. Predicted to localize to integral component of membrane. Is expressed in several structures, including median fin fold; mesoderm; nervous system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).
Genome Resources
Note
None
Expression
All Expression Data
28 figures from 12 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fras1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fraser syndrome 1 Alliance Fraser syndrome 1 219000
Associated With fras1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR003644 Na-Ca exchanger/integrin-beta4
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR038081 CalX-like domain superfamily
Repeat IPR006212 Furin-like repeat
Repeat IPR039005 CSPG repeat
Domain Details Per Protein
Protein Length CalX-like domain superfamily CSPG repeat EGF-like domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Na-Ca exchanger/integrin-beta4 VWFC domain
UniProtKB:A2BHG4 3936
UniProtKB:A0A0R4IQJ3 4003
UniProtKB:B6IDE3 3989
UniProtKB:D7PS88 4003
UniProtKB:A0A2R8QFB7 3977
UniProtKB:A0A2R8QDV4 3961
UniProtKB:A0A2R8QSM6 3978
UniProtKB:F1Q633 3970
UniProtKB:A0A2R8Q1V0 3997
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fras1 polyclonal Rabbit
  • IHC
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations