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ZIRC
ZFIN ID: ZDB-GENE-060526-68
Gene Name: Fraser extracellular matrix complex subunit 1
Gene Symbol: fras1    Nomenclature History

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Previous Names: id:ibd5080, pif (1), pinfin (1), si:ch211-191a6.5, wu:fc10b09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in several processes, including basement membrane organization; embryonic viscerocranium morphogenesis; and epithelial structure maintenance. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in Fraser syndrome. Is expressed in several structures, including epithelium; mesoderm; nervous system; pharyngeal arch; and trunk. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).
Genome Resources: Alliance (1),  Gene:563428 (1),  Ensembl(GRCz11):ENSDARG00000054619 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1048 Point Mutation Unknown Premature Stop ENU
b1130 Point Mutation Unknown Premature Stop ENU
la025056Tg Transgenic Insertion Unknown Unknown DNA
la025057Tg Transgenic Insertion Unknown Unknown DNA
mn0156Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14516 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17510 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20491 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20492 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20493 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25308 Point Mutation Unknown Premature Stop ENU
    sa26535 Point Mutation Unknown Premature Stop ENU
    sa33662 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33663 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33664 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40517 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45217 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • te262d Point Mutation Intron 42 Cryptic Acceptor Splice Site, Frameshift, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tj16 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm95b Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tr274 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fras1 N/A 1
    MO2-fras1 N/A 1
    DISEASE ASSOCIATED WITH fras1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Fraser syndrome 1 Alliance Fraser syndrome 1 219000
    DISEASE ASSOCIATED WITH fras1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process epithelial structure maintenance (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 9)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fras1-203 (1)    Ensembl 12999
    ncRNA fras1-002 (1) 505
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fras1 polyclonal Rabbit IHC Kimmel Lab
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fras1 No data available
    MARKER RELATIONSHIPS
    fras1 Contained in: [BAC] CH211-132F12 (1) (order this), CH211-191A6 (1) (order this), DKEY-29B15 (1) (order this)
    fras1 Encodes: [EST] fc10b09, ibd5080 (order this), IMAGE:7159429 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001130840 (1) 13101 bp
    Genomic GenBank:BX571800 (1) 195520 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IQJ3 (1) 4003 aa
    Sequence Clusters UniGene:77902 (1)
    Sequence Information (all 35)
    ORTHOLOGY for fras1 ( Chr: 5 )
    CITATIONS (34)