Gene
kank1a
- ID
- ZDB-GENE-060526-215
- Name
- KN motif and ankyrin repeat domains 1a
- Symbol
- kank1a Nomenclature History
- Previous Names
-
- ankrd15 (1)
- kank1
- si:dkey-146l2.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Is expressed in several structures, including fin; lateral plate mesoderm; notochord; optic vesicle; and otic placode. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 2. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Hensley et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa2225 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa2231 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa26558 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa45224 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
spastic quadriplegic cerebral palsy 2 | Alliance | Cerebral palsy, spastic quadriplegic, 2 | 612900 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
kank1a-202
(1)
|
Ensembl | 5,969 nt | ||
mRNA |
kank1a-203
(1)
|
Ensembl | 712 nt | ||
ncRNA |
kank1a-003
(1)
|
Ensembl | 613 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-146L2 | ZFIN Curated Data | |
Has Artifact | cDNA | MGC:153166 | ||
Has Artifact | cDNA | MGC:192882 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
Genomic | GenBank:CR388096 | 139460 nt |
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Cui, Z., Shen, Y., Chen, K.H., Mittal, S.K., Yang, J.Y., Zhang, G. (2017) KANK1 inhibits cell growth by inducing apoptosis though regulating CXXC5 in human malignant peripheral nerve sheath tumors. Scientific Reports. 7:40325
- Hensley, M.R., Cui, Z., Chua, R.F., Simpson, S., Shammas, N.L., Yang, J.Y., Leung, Y.F., Zhang, G. (2016) Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Scientific Reports. 6:27816
- Wirbisky, S.E., Damayanti, N.P., Mahapatra, C.T., Sepulveda, M.S., Irudayaraj, J., Freeman, J.L. (2016) Mitochondrial Dysfunction, Disruption of F-actin Polymerization, and Transcriptomic Alterations in Zebrafish Larvae Exposed to Trichloroethylene. Chemical Research in Toxicology. 29(2):169-79
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Boggetti, B., Jasik, J., Takamiya, M., Strähle, U., Reugels, A.M., and Campos-Ortega, J.A. (2012) NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Developmental Biology. 365(1):164-174
- Johnsen, H., and Andersen, O. (2012) Sex dimorphic expression of five dmrt genes identified in the Atlantic cod genome. The fish-specific dmrt2b diverged from dmrt2a before the fish whole-genome duplication. Gene. 505(2):221-232
- Shestopalov, I.A., Pitt, C.L., and Chen, J.K. (2012) Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development. Nature Chemical Biology. 8(3):270-276
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