Gene
map2k4a
- ID
- ZDB-GENE-060512-98
- Name
- mitogen-activated protein kinase kinase 4a
- Symbol
- map2k4a Nomenclature History
- Previous Names
-
- map2k4
- mkk4a (1)
- zgc:136500
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have JUN kinase kinase activity and protein serine/threonine kinase activity. Involved in determination of dorsal identity. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in ovarian serous carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Seo et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Rui et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B0Q3
|
393 | ||||
|
UniProtKB:A0A8M2BBT8
|
389 | ||||
|
UniProtKB:B1NA68
|
404 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map2k4a-201
(1)
|
Ensembl | 1,122 nt | ||
| mRNA |
map2k4a-202
(1)
|
Ensembl | 1,315 nt | ||
| mRNA |
map2k4a-203
(1)
|
Ensembl | 1,373 nt | ||
| mRNA |
map2k4a-204
(1)
|
Ensembl | 585 nt | ||
| mRNA |
map2k4a-205
(1)
|
Ensembl | 1,079 nt |
Interactions and Pathways
No data available
Plasmids
No data available