Gene

exosc5

ID

ZDB-GENE-060503-675

Name

exosome component 5

Symbol

exosc5 Nomenclature History

Previous Names

si:ch211-194n6.2
zgc:153707

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to be involved in RNA metabolic process. Predicted to localize to cytoplasmic exosome (RNase complex); nuclear exosome (RNase complex); and nucleolus. Orthologous to human EXOSC5 (exosome component 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Cabrera-Quio et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Slavotinek et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With exosc5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cerebellar ataxia, brain abnormalities, and cardiac conduction defects	619576

Associated With exosc5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001247	Exoribonuclease, phosphorolytic domain 1
Domain	IPR015847	Exoribonuclease, phosphorolytic domain 2
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR027408	PNPase/RNase PH domain superfamily
Homologous_superfamily	IPR036345	Exoribonuclease, PH domain 2 superfamily

Domain Details Per Protein

Protein	Length	Exoribonuclease, PH domain 2 superfamily	Exoribonuclease, phosphorolytic domain 1	Exoribonuclease, phosphorolytic domain 2	PNPase/RNase PH domain superfamily	Ribosomal protein uS5 domain 2-type superfamily
UniProtKB:A0A8M1NAS6 InterPro	230

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	exosc5-201 (1) Ensembl	Havana	705 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	exosc5-202 (1) Ensembl	Havana	486 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations