Gene

ar

ID
ZDB-GENE-060131-1
Name
androgen receptor
Symbol
ar Nomenclature History
Previous Names
  • Ar beta (1)
  • AR-A (1)
  • NR3C4 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits androgen binding activity; nuclear receptor activity; and steroid hormone receptor activity. Involved in gamete generation; male courtship behavior; and male gonad development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorders of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Is expressed in several structures, including digestive system; heart; male organism; nervous system; and pleuroperitoneal region. Orthologous to human AR (androgen receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ar Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
androgen insensitivity syndrome Alliance Androgen insensitivity 300068
hypogonadism Alliance Androgen insensitivity, partial, with or without breast cancer 312300
hypospadias Alliance Hypospadias 1, X-linked 300633
Kennedy's disease Alliance Spinal and bulbar muscular atrophy of Kennedy 313200
partial androgen insensitivity syndrome Alliance Androgen insensitivity, partial, with or without breast cancer 312300
prostate cancer Alliance {Prostate cancer, susceptibility to} 176807
Associated With ar Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:B3GN41 868
UniProtKB:A4GVF3 868
UniProtKB:Q6EAL5 377
UniProtKB:A4GT83 868
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations