Gene
hmgb2a
- ID
- ZDB-GENE-051120-126
- Name
- high mobility group box 2a
- Symbol
- hmgb2a Nomenclature History
- Previous Names
-
- hmgb2
- wu:fb22b10
- wu:fc95d12
- zgc:123215
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central nervous system; gut; neuromast; ovary; and pectoral fin bud. Orthologous to human HMGB2 (high mobility group box 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hmgb2a | N/A | Itou et al., 2011 |
| MO2-hmgb2a | N/A | Itou et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | High Mobility Group Box (HMGB) |
|---|---|---|---|---|---|
| UniProtKB:Q32PT3 | InterPro | 213 | |||
| UniProtKB:A0A8M1N808 | InterPro | 213 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmgb2a-201
(1)
|
Ensembl | 1,237 nt | ||
| mRNA |
hmgb2a-202
(1)
|
Ensembl | 862 nt | ||
| mRNA |
hmgb2a-204
(1)
|
Ensembl | 377 nt | ||
| ncRNA |
hmgb2a-002
(1)
|
Ensembl | 269 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-28D11 | ZFIN Curated Data | |
| Contains | STS | chunp30321 | ||
| Encodes | EST | fb22b10 | ||
| Encodes | EST | fc95d12 | ||
| Encodes | cDNA | MGC:123215 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037424 (1) | 1104 nt | ||
| Genomic | GenBank:CU462871 (1) | 113169 nt | ||
| Polypeptide | UniProtKB:A0A8M1N808 (1) | 213 aa |
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- Shen, W., Gong, B., Xing, C., Zhang, L., Sun, J., Chen, Y., Yang, C., Yan, L., Chen, L., Yao, L., Li, G., Deng, H., Wu, X., Meng, A. (2022) Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell. 185(26):4954-4970.e20
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Yu, S., He, J. (2019) Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish. eLIFE. 8
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630
- Rao, Y., Su, J., Yang, C., Peng, L., Feng, X., and Li, Q. (2013) Characterizations of two grass carp Ctenopharyngodon idella HMGB2 genes and potential roles in innate immunity. Developmental and comparative immunology. 41(2):164-177
- Cuello, S., Ximénez-Embún, P., Ruppen, I., Schonthaler, H.B., Ashman, K., Madrid, Y., Luque-Garcia, J.L., and Cámara, C. (2012) Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. The Analyst. 137(22):5302-5311
- Itou, J., Taniguchi, N., Oishi, I., Kawakami, H., Lotz, M., and Kawakami, Y. (2011) HMGB factors are required for posterior digit development through integrating signaling pathway activities. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(5):1151-1162
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