Gene
herpud1
- ID
- ZDB-GENE-050913-47
- Name
- homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
- Symbol
- herpud1 Nomenclature History
- Previous Names
-
- zgc:114134
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum unfolded protein response; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in telencephalon. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa25059 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 /2 | Ubiquitin-like domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A286YAA4 | InterPro | 408 | |||
| UniProtKB:A0A8M2B5Q0 | InterPro | 401 | |||
| UniProtKB:Q4V8U9 | InterPro | 402 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
herpud1-201
(1)
|
Ensembl | 2,043 nt | ||
| aberrant processed transcript |
herpud1-202
(1)
|
Ensembl | 618 nt | ||
| mRNA |
herpud1-203
(1)
|
Ensembl | 1,243 nt | ||
| mRNA |
herpud1-204
(1)
|
Ensembl | 2,209 nt | ||
| mRNA |
herpud1-205
(1)
|
Ensembl | 5,657 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-122C9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114134 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025537 (1) | 2231 nt | ||
| Genomic | GenBank:BX470170 (1) | 108112 nt | ||
| Polypeptide | UniProtKB:A0A286YAA4 (1) | 408 aa |
- Elbialy, A., Sulidan, K., Bhuiyan, A., Igarashi, Y., Yoshitake, K., Yamanouchi, D., Kang, J., Asakawa, S., Watabe, S., Kinoshita, S. (2022) Induction of endoplasmic reticulum stress markers in an acromegaly model. Journal of cellular biochemistry. 123(9):1411-1421
- Nair, A.R., Lakhiani, P., Zhang, C., Macchi, F., Sadler, K.C. (2021) A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver. Genomics. 114(1):107-124
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Pfeiffer, J., Tarbashevich, K., Bandemer, J., Palm, T., Raz, E. (2018) Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - the role of Hsp90. Developmental Biology. 436(2):84-93
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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