Gene

esco2

ID

ZDB-GENE-050913-156

Name

establishment of sister chromatid cohesion N-acetyltransferase 2

Symbol

esco2 Nomenclature History

Previous Names

loc157570
si:dkey-217m5.6
un-named hi2865
unm hi2865
zgc:111795 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have acetyltransferase activity. Involved in several processes, including positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; sister chromatid cohesion; and tissue regeneration. Predicted to localize to chromatin. Used to study Roberts syndrome. Human ortholog(s) of this gene implicated in Roberts syndrome and SC phocomelia syndrome. Is expressed in digestive system; heart; nervous system; otic vesicle; and pectoral fin. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:111795 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With esco2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Roberts syndrome	Alliance	Roberts-SC phocomelia syndrome	268300
		Juberg-Hayward syndrome	216100

Associated With esco2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Roberts syndrome	esco2^{hi2865Tg/hi2865Tg}	standard conditions	Xu et al., 2013
Roberts syndrome	WT + MO1-esco2	standard conditions	(2)
Roberts syndrome	esco2^{hi2865Tg/hi2865Tg}	standard conditions	Percival et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR028005	N-acetyltransferase ESCO, zinc-finger
Domain	IPR028009	N-acetyltransferase ESCO, acetyl-transferase domain

Domain Details Per Protein

Protein	Length	N-acetyltransferase ESCO, acetyl-transferase domain	N-acetyltransferase ESCO, zinc-finger
UniProtKB:Q5SPR8 InterPro	609
UniProtKB:A0A8M2B7P6 InterPro	608

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	esco2-201 (1) Ensembl	Ensembl		2,339 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-esco2	polyclonal	esco2		Rabbit	WB		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations