Gene

lats1

ID
ZDB-GENE-050523-2
Name
large tumor suppressor kinase 1
Symbol
lats1 Nomenclature History
Previous Names
  • si:dkey-181i3.5
  • wu:fc19a11
  • zgc:123219
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in BMP signaling pathway; convergent extension involved in gastrulation; and secondary heart field specification. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Orthologous to human LATS1 (large tumor suppressor kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Chen et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Chen et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lats1 Human Ortholog
No data available
Associated With lats1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Family IPR028741 Serine/threonine-protein kinase LATS1
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase LATS1
UniProtKB:Q58FB8 1068
UniProtKB:Q5RIL6 1068
UniProtKB:Q32PN2 444
UniProtKB:A9JTE1 632
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations