Gene
cyp2y3
- ID
- ZDB-GENE-050522-490
- Name
- cytochrome P450, family 2, subfamily Y, polypeptide 3
- Symbol
- cyp2y3 Nomenclature History
- Previous Names
-
- im:6903403
- sb:cb637
- zgc:110692
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including EVL; pectoral fin musculature; periderm; visual system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including drug dependence (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including CYP2A13 (cytochrome P450 family 2 subfamily A member 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb637 (17 images)
- IMAGE:6903403 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012811Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa815 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2784 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42457 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 family 2 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q4VBR9
|
491 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp2y3-201
(1)
|
Ensembl | 1,476 nt | ||
| mRNA |
cyp2y3-202
(1)
|
Ensembl | 2,295 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-83N3 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-411A11 | ZFIN Curated Data | |
| Encodes | EST | cb637 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6903403 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110692 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020822 (1) | 2325 nt | ||
| Genomic | GenBank:CU928854 | 39669 nt | ||
| Polypeptide | UniProtKB:Q4VBR9 (1) | 491 aa |
No data available
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Han, S.C., Huang, R.P., Zhang, Q.Y., Yan, C.Y., Li, X.Y., Li, Y.F., He, R.R., Li, W.X. (2023) Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models. Foods (Basel, Switzerland). 12(5):
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Shihana, F., Cholan, P.M., Fraser, S., Oehlers, S.H., Seth, D. (2023) Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (Danio rerio). Liver international : official journal of the International Association for the Study of the Liver. 43(11):2455-2468
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Weeks, O., Miller, B.M., Pepe-Mooney, B.J., Oderberg, I.M., Freeburg, S.H., Smith, C.J., North, T.E., Goessling, W. (2022) Embryonic alcohol exposure disrupts the ubiquitin-proteasome system. JCI insight. 7(23):
- Navarrete, J., Wilson, P., Allsing, N., Gordon, C., Margolis, R., Schwartz, A.V., Cho, C., Rogowski, B., Topps, J., George, U.Z., Sant, K.E. (2021) The ecotoxicological contaminant tris(4-chlorophenyl)methanol (TCPMOH) impacts embryonic development in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 235:105815
- Liu, Y.S., Yuan, M.H., Zhang, C.Y., Liu, H.M., Liu, J.R., Wei, A.L., Ye, Q., Zeng, B., Li, M.F., Guo, Y.P., Guo, L. (2020) Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 134:111121
- Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
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