Gene
apoea
- ID
- ZDB-GENE-010724-18
- Name
- apolipoprotein Ea
- Symbol
- apoea Nomenclature History
- Previous Names
-
- ApoE-1 (1)
- im:7036787
- wu:fb69a05
- zgc:110064
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have lipid binding activity. Predicted to be involved in lipid transport and lipoprotein metabolic process. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Is expressed in brain; female organism; male organism; and yolk syncytial layer. Orthologous to human APOE (apolipoprotein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110064 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hwang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 1 | Alliance | {?Macular degeneration, age-related} | 603075 |
| Alzheimer's disease 2 | Alliance | Alzheimer disease 2 | 104310 |
| Alzheimer's disease 3 | Alliance | {?Alzheimer disease, protection against, due to APOE3-Christchurch} | 607822 |
| hyperlipoproteinemia type III | Alliance | Hyperlipoproteinemia, type III | 617347 |
| hyperlipoproteinemia type III | Alliance | {Coronary artery disease, severe, susceptibility to} | 617347 |
| sea-blue histiocytosis | Alliance | Sea-blue histiocyte disease | 269600 |
| Lipoprotein glomerulopathy | 611771 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000074 | Apolipoprotein A/E |
Domain Details Per Protein
| Protein | Length | Apolipoprotein A/E |
|---|---|---|
|
UniProtKB:Q503V2
|
269 |
Interactions and Pathways
No data available
Plasmids