Gene

cyb5r4

ID
ZDB-GENE-050522-225
Name
cytochrome b5 reductase 4
Symbol
cyb5r4 Nomenclature History
Previous Names
  • ncb5or (1)
  • im:4727699
  • zgc:112177
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have cytochrome-b5 reductase activity, acting on NAD(P)H and heme binding activity. Predicted to be involved in generation of precursor metabolites and energy and superoxide metabolic process. Predicted to localize to endoplasmic reticulum. Is expressed in blood vasculature. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Weber et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyb5r4 Human Ortholog
No data available
Associated With cyb5r4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018506 Cytochrome b5, heme-binding site
Domain IPR001199 Cytochrome b5-like heme/steroid binding domain
Domain IPR001433 Oxidoreductase FAD/NAD(P)-binding
Domain IPR007052 CS domain
Domain IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Domain IPR037908 Cytochrome b5 reductase 4, p23 domain
Family IPR001834 NADH:cytochrome b5 reductase-like
Homologous_superfamily IPR008978 HSP20-like chaperone
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length CS domain Cytochrome b5, heme-binding site Cytochrome b5-like heme/steroid binding domain Cytochrome b5-like heme/steroid binding domain superfamily Cytochrome b5 reductase 4, p23 domain FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain HSP20-like chaperone NADH:cytochrome b5 reductase-like Oxidoreductase FAD/NAD(P)-binding Riboflavin synthase-like beta-barrel
UniProtKB:Q502I6 527
UniProtKB:F1QIA4 527
UniProtKB:A0A0R4IB98 515
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations