Gene
cyb5r4
- ID
- ZDB-GENE-050522-225
- Name
- cytochrome b5 reductase 4
- Symbol
- cyb5r4 Nomenclature History
- Previous Names
-
- ncb5or (1)
- im:4727699
- zgc:112177
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have cytochrome-b5 reductase activity, acting on NAD(P)H and heme binding activity. Predicted to be involved in generation of precursor metabolites and energy and superoxide metabolic process. Predicted to localize to endoplasmic reticulum. Is expressed in blood vasculature. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Weber et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018506 | Cytochrome b5, heme-binding site |
| Domain | IPR001199 | Cytochrome b5-like heme/steroid binding domain |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR007052 | CS domain |
| Domain | IPR008333 | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Domain | IPR037908 | Cytochrome b5 reductase 4, p23 domain |
| Family | IPR001834 | NADH:cytochrome b5 reductase-like |
| Homologous_superfamily | IPR008978 | HSP20-like chaperone |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR036400 | Cytochrome b5-like heme/steroid binding domain superfamily |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
| Protein | Length | CS domain | Cytochrome b5, heme-binding site | Cytochrome b5-like heme/steroid binding domain | Cytochrome b5-like heme/steroid binding domain superfamily | Cytochrome b5 reductase 4, p23 domain | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | HSP20-like chaperone | NADH:cytochrome b5 reductase-like | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q502I6
|
527 | ||||||||||||
|
UniProtKB:F1QIA4
|
527 | ||||||||||||
|
UniProtKB:A0A0R4IB98
|
515 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available