Gene
cyb5r4
- ID
- ZDB-GENE-050522-225
- Name
- cytochrome b5 reductase 4
- Symbol
- cyb5r4 Nomenclature History
- Previous Names
-
- ncb5or (1)
- im:4727699
- zgc:112177
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H and heme binding activity. Predicted to be involved in superoxide metabolic process. Predicted to be active in endoplasmic reticulum. Is expressed in blood vasculature. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Weber et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018506 | Cytochrome b5, heme-binding site |
| Domain | IPR001199 | Cytochrome b5-like heme/steroid binding domain |
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR007052 | CS domain |
| Domain | IPR008333 | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Domain | IPR037908 | Cytochrome b5 reductase 4, p23 domain |
| Family | IPR051872 | Cytochrome b5/Flavoprotein Reductase |
| Homologous_superfamily | IPR008978 | HSP20-like chaperone |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR036400 | Cytochrome b5-like heme/steroid binding domain superfamily |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | CS domain | Cytochrome b5/Flavoprotein Reductase | Cytochrome b5, heme-binding site | Cytochrome b5-like heme/steroid binding domain | Cytochrome b5-like heme/steroid binding domain superfamily | Cytochrome b5 reductase 4, p23 domain | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | HSP20-like chaperone | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BKQ7 | InterPro | 577 | ||||||||||||
| UniProtKB:Q502I6 | InterPro | 527 | ||||||||||||
| UniProtKB:A0A8M2BKQ3 | InterPro | 312 | ||||||||||||
| UniProtKB:A0AB32T4D1 | InterPro | 565 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyb5r4-201
(1)
|
Ensembl | 2,656 nt | ||
| mRNA |
cyb5r4-202
(1)
|
Ensembl | 1,548 nt |
Interactions and Pathways
No data available
Plasmids
No data available