Gene

gsr

ID

ZDB-GENE-050522-116

Name

glutathione reductase

Symbol

gsr Nomenclature History

Previous Names

zgc:110010 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable flavin adenine dinucleotide binding activity and glutathione-disulfide reductase (NADPH) activity. Acts upstream of or within cell redox homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in intestinal bulb; liver; and macrophage. Human ortholog(s) of this gene implicated in cataract; congenital nonspherocytic hemolytic anemia 10; and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110010 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gsr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia 10	Alliance	Anemia, congenital, nonspherocytic hemolytic, 10, glutathione reductase deficient	618660

Associated With gsr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR012999	Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Domain	IPR004099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Domain	IPR023753	FAD/NAD(P)-binding domain
Family	IPR001100	Pyridine nucleotide-disulphide oxidoreductase, class I
Family	IPR006322	Glutathione reductase, eukaryote/bacterial
Family	IPR046952	Glutathione reductase/thioredoxin reductase-like
Homologous_superfamily	IPR016156	FAD/NAD-linked reductase, dimerisation domain superfamily
Homologous_superfamily	IPR036188	FAD/NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	FAD/NAD-linked reductase, dimerisation domain superfamily	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain superfamily	Glutathione reductase, eukaryote/bacterial	Glutathione reductase/thioredoxin reductase-like	Pyridine nucleotide-disulphide oxidoreductase, class I	Pyridine nucleotide-disulphide oxidoreductase, class I, active site	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
UniProtKB:Q503Y5 InterPro	425
UniProtKB:A0A8M6Z2M1 InterPro	500
UniProtKB:A0A8M9QB21 InterPro	469

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	gsr-205 (1) Ensembl	Ensembl	870 nt	Select Tool ZFIN BLAST
mRNA	gsr-201 (1) Ensembl	Ensembl	1,976 nt	Select Tool ZFIN BLAST
mRNA	gsr-202 (1) Ensembl	Ensembl	1,545 nt	Select Tool ZFIN BLAST
mRNA	gsr-206 (1) Ensembl	Ensembl	1,318 nt	Select Tool ZFIN BLAST
mRNA	gsr-207 (1) Ensembl	Ensembl	895 nt	Select Tool ZFIN BLAST
mRNA	gsr-208 (1) Ensembl	Ensembl	660 nt	Select Tool ZFIN BLAST
mRNA	gsr-209 (1) Ensembl	Ensembl	1,290 nt	Select Tool ZFIN BLAST
ncRNA	gsr-003 (1) Ensembl	Ensembl	814 nt	Select Tool ZFIN BLAST
ncRNA	gsr-004 (1) Ensembl	Ensembl	567 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations