abcc12

ID

ZDB-GENE-050517-25

Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 12

Symbol

abcc12 Nomenclature History

Previous Names

mrp9 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ATPase-coupled transmembrane transporter activity. Acts upstream of or within regulation of cholangiocyte apoptotic process. Predicted to be active in membrane. Is expressed in brain; intestine; intrahepatic bile duct; liver; and pancreas. Orthologous to several human genes including ABCC12 (ATP binding cassette subfamily C member 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Pham et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Pham et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abcc12 Human Ortholog

No data available

Associated With abcc12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR011527	ABC transporter type 1, transmembrane domain
Family	IPR050173	ATP-binding cassette transporter C-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036640	ABC transporter type 1, transmembrane domain superfamily