Gene
sema3fb
- ID
- ZDB-GENE-050513-2
- Name
- sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb
- Symbol
- sema3fb Nomenclature History
- Previous Names
-
- sema3f2 (1)
- sb:cb931
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables neuropilin binding activity. Acts upstream of or within cardiac chamber development; heart valve development; and neutrophil clearance. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; forebrain neural keel; hypochord; neural plate; and pericardial region. Orthologous to human SEMA3F (semaphorin 3F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb931 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ca305 | Allele with one deletion | Exon 2 | Unknown | not specified | |
| ca306 | Allele with one insertion | Exon 2 | Unknown | not specified | |
| la012019Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027274Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13129 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14466 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24893 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35134 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38853 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sh373 | Allele with one insertion | Unknown | Unknown | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Plexin repeat | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BK66
|
787 | |||||||||||
|
UniProtKB:A0A2R8Q5T8
|
791 | |||||||||||
|
UniProtKB:A0A8M9Q3U2
|
761 | |||||||||||
|
UniProtKB:A0A8M3AXT1
|
791 | |||||||||||
|
UniProtKB:A0A8M9Q0L0
|
757 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema3fb-201
(1)
|
Ensembl | 5,761 nt | ||
| mRNA |
sema3fb-202
(1)
|
Ensembl | 6,946 nt | ||
| mRNA |
sema3fb-203
(1)
|
Ensembl | 6,856 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196F4 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-92B10 | ZFIN Curated Data | |
| Encodes | EST | cb931 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068224389 (1) | 5773 nt | ||
| Genomic | GenBank:CU302307 (1) | 178447 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q5T8 (1) | 791 aa |
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Cheng, R.P., Dang, P., Taku, A.A., Moon, Y.J., Pham, V., Sun, X., Zhao, E., Raper, J.A. (2022) Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting. Neural Development. 17:1
- Halabi, R., Cechmanek, P.B., Hehr, C.L., McFarlane, S. (2022) Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development. Cell communication and signaling : CCS. 20:126
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Watterston, C., Halabi, R., McFarlane, S., Childs, S.J. (2021) Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting. PLoS Genetics. 17:e1009769
- Plant, T., Eamsamarng, S., Sanchez-Garcia, M.A., Reyes, L., Renshaw, S.A., Coelho, P., Mirchandani, A.S., Morgan, J.M., Ellett, F.E., Morrison, T., Humphries, D., Watts, E.R., Murphy, F., Raffo-Iraolagoitia, X.L., Zhang, A., Cash, J.L., Loynes, C., Elks, P.M., Van Eeden, F., Carlin, L.M., Furley, A.J.W., Whyte, M.K.B., Walmsley, S.R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. The Journal of Clinical Investigation. 130(6):3221-3237
- Weinberger, M., Simões, F.C., Patient, R., Sauka-Spengler, T., Riley, P.R. (2020) Functional Heterogeneity within the Developing Zebrafish Epicardium. Developmental Cell. 52(5):574-590.e6
- He, Z., Crenshaw, E., Raper, J.A. (2019) Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. Biochemical and Biophysical Research Communications. 517(1):23-28
- van der Klaauw, A.A., Croizier, S., Mendes de Oliveira, E., Stadler, L.K.J., Park, S., Kong, Y., Banton, M.C., Tandon, P., Hendricks, A.E., Keogh, J.M., Riley, S.E., Papadia, S., Henning, E., Bounds, R., Bochukova, E.G., Mistry, V., O'Rahilly, S., Simerly, R.B., INTERVAL, UK10K Consortium, Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G., Farooqi, I.S. (2019) Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 176(4):729-742.e18
- Ward, R., Ali, Z., Slater, K., Reynolds, A.L., Jensen, L.D., Kennedy, B.N. (2019) Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease. Developmental Biology. 457(2):226-234
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