Gene

vcla

ID
ZDB-GENE-050506-61
Name
vinculin a
Symbol
vcla Nomenclature History
Previous Names
  • vcl
  • hm:zehn2160
  • im:6902790
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity and structural molecule activity. Involved in several processes, including atrioventricular valve morphogenesis; membrane repolarization during cardiac muscle cell action potential; and sarcomere organization. Localizes to adherens junction and focal adhesion. Is expressed in several structures, including heart; lens; pectoral fin; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vcla Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1W Alliance Cardiomyopathy, dilated, 1W 611407
hypertrophic cardiomyopathy 15 Alliance Cardiomyopathy, hypertrophic, 15 613255
Associated With vcla Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000633 Vinculin, conserved site
Family IPR006077 Vinculin/alpha-catenin
Family IPR017997 Vinculin
Homologous_superfamily IPR036723 Alpha-catenin/vinculin-like superfamily
Domain Details Per Protein
Protein Length Alpha-catenin/vinculin-like superfamily Vinculin Vinculin/alpha-catenin Vinculin, conserved site
UniProtKB:Q567Z1 484
UniProtKB:B8JIH2 1131
UniProtKB:B3DI32 1131
UniProtKB:A3KNT5 485
UniProtKB:F6NHA0 1066
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab6-vcl monoclonal IgG1 Mouse
  • IHC
Sigma-Aldrich
8
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations