Gene

vcla

ID

ZDB-GENE-050506-61

Name

vinculin a

Symbol

vcla Nomenclature History

Previous Names

vcl
hm:zehn2160
im:6902790

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable alpha-catenin binding activity and beta-catenin binding activity. Involved in heart contraction. Acts upstream of or within atrioventricular valve morphogenesis; membrane repolarization during cardiac muscle cell action potential; and sarcomere organization. Located in adherens junction. Is active in focal adhesion. Is expressed in several structures, including heart; lens; pectoral fin; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6902790 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vcla Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1W	Alliance	Cardiomyopathy, dilated, 1W	611407
hypertrophic cardiomyopathy 15	Alliance	Cardiomyopathy, hypertrophic, 15	613255

Associated With vcla Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000633	Vinculin, conserved site
Family	IPR006077	Vinculin/alpha-catenin
Family	IPR017997	Vinculin
Homologous_superfamily	IPR036723	Alpha-catenin/vinculin-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:F6NHA0	InterPro	1066
UniProtKB:A0A8M2B3M1	InterPro	1130
UniProtKB:A0A8M9QJN2	InterPro	1067
UniProtKB:B3DI32	InterPro	1131

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vcla-201 (1) Ensembl	Ensembl	3,756 nt	Select Tool ZFIN BLAST
mRNA	vcla-202 (1) Ensembl	Ensembl	4,069 nt	Select Tool ZFIN BLAST
ncRNA	vcla-002 (1) Ensembl	Ensembl	491 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab6-vcl	monoclonal	vcla	IgG1	Mouse	IHC WB	Sigma-Aldrich	15

Plasmids

Addgene:185410

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations