Gene
fat1a
- ID
- ZDB-GENE-050425-1
- Name
- FAT atypical cadherin 1a
- Symbol
- fat1a Nomenclature History
- Previous Names
-
- fat1
- fat
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Involved in pronephros development. Predicted to localize to membrane. Is expressed in several structures, including digestive system; nervous system; otic vesicle; pleuroperitoneal region; and tail bud. Orthologous to human FAT1 (FAT atypical cadherin 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu651 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa494 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa1140 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa1599 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12774 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa13483 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa14711 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa24837 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa25555 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa32637 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38253 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-fat1a | Lahrouchi et al., 2019 | |
MO1-fat1a | N/A | (2) |
MO2-fat1a | N/A | Lahrouchi et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Laminin G domain | NOTCH1 EGF-like calcium-binding domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PRG7
|
4666 | |||||||||||
UniProtKB:A0A8M9PV49
|
4643 | |||||||||||
UniProtKB:A2BGT8
|
4611 | |||||||||||
UniProtKB:A0A8M2BFN2
|
4634 | |||||||||||
UniProtKB:A0A8M2BG88
|
4646 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-194C21 | ZFIN Curated Data | |
Contained in | BAC | CH211-197N1 | ZFIN Curated Data | |
Contained in | BAC | DKEY-32G22 | ZFIN Curated Data | |
Contained in | BAC | DKEY-228C11 | ZFIN Curated Data | |
Encodes | EST | eu651 | Thisse et al., 2005 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212967 (1) | 14166 nt | ||
Genomic | GenBank:BX323008 (1) | 216850 nt | ||
Polypeptide | UniProtKB:A0A8M9PRG7 (1) | 4666 aa |
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Gasanov, E.V., Jędrychowska, J., Kuźnicki, J., Korzh, V. (2021) Evolutionary context can clarify gene names: Teleosts as a case study. BioEssays : news and reviews in molecular, cellular and developmental biology. 43(6):e2000258
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Loontiens, S., Vanhauwaert, S., Depestel, L., Dewyn, G., Van Loocke, W., Moore, F.E., Garcia, E.G., Batchelor, L., Borga, C., Squiban, B., Malone-Perez, M., Volders, P.J., Olexiouk, V., Van Vlierberghe, P., Langenau, D.M., Frazer, J.K., Durinck, K., Speleman, F. (2020) A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia. 34(12):3398-3403
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Lahrouchi, N., George, A., Ratbi, I., Schneider, R., Elalaoui, S.C., Moosa, S., Bharti, S., Sharma, R., Abu-Asab, M., Onojafe, F., Adadi, N., Lodder, E.M., Laarabi, F.Z., Lamsyah, Y., Elorch, H., Chebbar, I., Postma, A.V., Lougaris, V., Plebani, A., Altmueller, J., Kyrieleis, H., Meiner, V., McNeill, H., Bharti, K., Lyonnet, S., Wollnik, B., Henrion-Caude, A., Berraho, A., Hildebrandt, F., Bezzina, C.R., Brooks, B.P., Sefiani, A. (2019) Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly. Nature communications. 10:1180
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26
- Gee, H.Y., Sadowski, C.E., Aggarwal, P.K., Porath, J.D., Yakulov, T.A., Schueler, M., Lovric, S., Ashraf, S., Braun, D.A., Halbritter, J., Fang, H., Airik, R., Vega-Warner, V., Cho, K.J., Chan, T.A., Morris, L.G., Ffrench-Constant, C., Allen, N., McNeill, H., Büscher, R., Kyrieleis, H., Wallot, M., Gaspert, A., Kistler, T., Milford, D.V., Saleem, M.A., Keng, W.T., Alexander, S.I., Valentini, R.P., Licht, C., Teh, J.C., Bogdanovic, R., Koziell, A., Bierzynska, A., Soliman, N.A., Otto, E.A., Lifton, R.P., Holzman, L.B., Sibinga, N.E., Walz, G., Tufro, A., Hildebrandt, F. (2016) FAT1 mutations cause a glomerulotubular nephropathy. Nature communications. 7:10822
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