ZFIN is now using GRCz12tu for Genomic Data
Gene
carmil2
- ID
- ZDB-GENE-050419-197
- Name
- capping protein regulator and myosin 1 linker 2
- Symbol
- carmil2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in cell migration and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be located in cytoplasm. Predicted to be active in lamellipodium and plasma membrane. Is expressed in central nervous system; eye; and pronephric duct. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to human CARMIL2 (capping protein regulator and myosin 1 linker 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Stark et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 58 | Alliance | Immunodeficiency 58 | 618131 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR031943 | CARMIL, C-terminal domain |
| Domain | IPR041245 | CARMIL, pleckstrin homology domain |
| Family | IPR051279 | Protein Phosphatase 1 Regulatory and Actin Interaction Protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | CARMIL, C-terminal domain | CARMIL, pleckstrin homology domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | PH-like domain superfamily | Protein Phosphatase 1 Regulatory and Actin Interaction Protein |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6NI44 | InterPro | 1665 | ||||||
| UniProtKB:A0A8M9PQB9 | InterPro | 1006 | ||||||
| UniProtKB:A0AC58HU45 | InterPro | 1678 | ||||||
| UniProtKB:A0AC58HU46 | InterPro | 1667 | ||||||
| UniProtKB:A0AC58HU49 | InterPro | 1427 | ||||||
| UniProtKB:A0AC58HU51 | InterPro | 1534 | ||||||
| UniProtKB:A0AC58HU53 | InterPro | 1664 | ||||||
| UniProtKB:A0AC58HU56 | InterPro | 1662 | ||||||
| UniProtKB:A0AC58HU57 | InterPro | 1424 | ||||||
| UniProtKB:A0AC58HU58 | InterPro | 1531 | ||||||
| UniProtKB:A0AC58HU59 | InterPro | 1567 | ||||||
| UniProtKB:A0AC58HU61 | InterPro | 1427 | ||||||
| UniProtKB:A0AC58HU62 | InterPro | 1424 | ||||||
| UniProtKB:A0AC58HU63 | InterPro | 1388 | ||||||
| UniProtKB:A0AC58HU67 | InterPro | 1427 | ||||||
| UniProtKB:A0AC58HU88 | InterPro | 1427 | ||||||
| UniProtKB:A0AC58HU91 | InterPro | 1427 | ||||||
| UniProtKB:A0AC58HUC5 | InterPro | 1570 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
carmil2-201
(1)
|
Ensembl | 5,241 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers