Gene

stk11

ID
ZDB-GENE-050417-383
Name
serine/threonine kinase 11
Symbol
stk11 Nomenclature History
Previous Names
  • lkb1 (1)
  • wu:fj61a05
  • zgc:110180
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in several processes, including energy homeostasis; glucose homeostasis; and intestinal epithelial cell differentiation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; endometrial cancer; ovarian carcinoma; and pancreatic cancer. Is expressed in digestive system; head; and trunk. Orthologous to human STK11 (serine/threonine kinase 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stk11 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pancreatic carcinoma Alliance Pancreatic cancer, somatic 260350
Peutz-Jeghers syndrome Alliance Peutz-Jeghers syndrome 175200
testicular germ cell cancer Alliance Testicular tumor, somatic 273300
Melanoma, malignant, somatic 155600
Associated With stk11 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR039154 Serine/Threonine kinase LKB1, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/Threonine kinase LKB1, catalytic domain Serine/threonine-protein kinase, active site
UniProtKB:Q568P5
InterPro
440
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA stk11-201 (1)
Ensembl
Ensembl 2,118 nt
ZFIN BLAST
mRNA stk11-202 (1)
Ensembl
Ensembl 1,320 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-stk11 polyclonal Rabbit
  • IHC
 Bioworld
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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