Gene
srd5a2a
- ID
- ZDB-GENE-050417-199
- Name
- steroid-5-alpha-reductase, alpha polypeptide 2a
- Symbol
- srd5a2a Nomenclature History
- Previous Names
-
- wu:fk70d02
- zgc:109942
- zgc:112208
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Predicted to be involved in steroid biosynthetic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Is expressed in intestinal bulb and liver. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109942 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pseudovaginal perineoscrotal hypospadias | 264600 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 3-oxo-5-alpha-steroid 4-dehydrogenase | 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal | 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase |
|---|---|---|---|---|
|
UniProtKB:Q566Z4
|
252 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
srd5a2a-202
(1)
|
Ensembl | 859 nt | ||
| mRNA |
srd5a2a-201
(1)
|
Ensembl | 1,155 nt | ||
| ncRNA |
srd5a2a-002
(1)
|
Ensembl | 1,630 nt |
Interactions and Pathways
No data available
Plasmids
No data available